ArticleThe Journal of physiology2022
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance.
Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Fetal and post-natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta-analysis of animal experiments.Diabetic medicine : a journal of the British Diabetic Association · 2024Pooled it
- Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes.Molecular and cellular pediatrics · 2026Article
- A high-fat, high-sugar diet impairs maternal metabolism throughout pregnancy and lactation in mice.The Journal of physiology · 2026Article
- Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse.The Journal of physiology · 2026Article
- Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation†.Biology of reproduction · 2025Article
- Incretin receptor agonism during pregnancy: implications for mother and baby.Clinical science (London, England : 1979) · 2025Review
- RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cardiovascular outcome in 12-month-old male and female offspring of metformin-treated obese mice.The Journal of physiology · 2025Article
- Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.American journal of obstetrics and gynecology · 2024Article
- Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2.Cellular and molecular life sciences : CMLS · 2024Article
- Absence of Metformin in Fetal Circulation Following Maternal Administration in Late Gestation Pregnant Sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The metabolic response of human trophoblasts derived from term placentas to metformin.Diabetologia · 2023Article
- Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Article
- Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring.Diabetologia · 2022Article
- Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta.Physiological reports · 2022Article
- Sex differences in the intergenerational inheritance of metabolic traits.Nature metabolism · 2022Review
- Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia.The Journal of endocrinology · 2022Review
- Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress.Frontiers in cell and developmental biology · 2022Article
- Genetics, epigenetics and transgenerational transmission of obesity in children.Frontiers in endocrinology · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal obesity is a global problem that increases the risk of short- and long-term adverse outcomes for mother and child, many of which are linked to gestational diabetes mellitus. Effective treatments are essential to prevent the transmission of poor metabolic health from mother to child. Metformin is an effective glucose lowering drug commonly used to treat gestational diabetes mellitus; however, its wider effects on maternal and fetal health are poorly explored. In this study we used a mouse (C57Bl6/J) model of diet-induced (high sugar/high fat) maternal obesity to explore the impact of metformin on maternal and feto-placental health. Metformin (300 mg kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.