Evidence map›Paper›PMID 34505210›Full record

ArticleJournal of biomolecular NMR2021

Evaluation of the tert-butyl group as a probe for NMR studies of macromolecular complexes.

Rashmi Voleti, Sofia Bali, Jaime Guerrero, Jared Smothers, Charis Springhower, Gerardo A Acosta, Kyle D Brewer, Fernando Albericio, Josep Rizo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular NMR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Rashmi VoletiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Sofia Bali *Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jaime Guerrero *Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jared Smothers *Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Charis Springhower *Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Gerardo A AcostaCIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain.
Kyle D BrewerDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Fernando AlbericioCIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain.
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Jose.Rizo-Rey@UTSouthwestern.edu.ORCID http://orcid.org/0000-0003-1773-8311
The University of Texas Southwestern Medical Center · USConsejo Superior de Investigaciones Científicas · ESScientific Technologies Corporation (United States) · USSouthwestern Medical Center · US

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
Molecular Biophysics Training ProgramT32GM131963 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Luke W Rice · 2019 to 2026
$1.5M
Acquisition of upgrades for 800 MHz NMR consoleS10OD018027 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2014 to 2014
$376k
NIGMS NIH HHS T32 GM131963NIH HHS S10 OD018027NINDS NIH HHS NS097333NINDS NIH HHS R35 NS097333Welch Foundation I-1304
6 · The paper itself

Abstract

The development of methyl transverse relaxation optimized spectroscopy has greatly facilitated the study of macromolecular assemblies by solution NMR spectroscopy. However, limited sample solubility and stability has hindered application of this technique to ongoing studies of complexes formed on membranes by the neuronal SNAREs that mediate neurotransmitter release and synaptotagmin-1, the Ca

Indexed as

NeuronsSNARE ProteinsMacromolecular SubstancesMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularMacromolecular SubstancesSNARE ProteinsComplexinMacromolecular assembliesNeurotransmitter releaseSlow relaxationSNARE complexSynaptotagminTert-butyl NMR

Identifiers

PMID34505210
PMCPMC9482097
OpenAlexW3198717997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.