Evidence map›Paper›PMID 34505162›Full record

ArticleExperimental brain research2021

Exploring the effect of capsaicin-induced central sensitization on the upper limb nociceptive withdrawal reflex threshold.

Lukas D Linde, Leah R Bent, James P Dickey, Dinesh A Kumbhare, John Z Srbely

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Article in Experimental brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lukas D LindeInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. lukas.linde@ubc.ca.ORCID http://orcid.org/0000-0001-5180-4904
Leah R BentDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
James P DickeySchool of Kinesiology, Western University, London, ON, Canada.
Dinesh A KumbhareDepartment of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, ON, Canada.
John Z SrbelyDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
University of Guelph · CAUniversity of British Columbia Hospital · CAUniversity of Toronto · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nociceptive withdrawal reflex (NWR) threshold is commonly employed in the lower limb to assess clinical and experimentally induced pain. However, no studies to date have investigated changes in spinal nociception in the upper limb, via the NWR threshold, following experimentally induced central sensitization (CS). We tested the hypothesis that experimentally induced CS of the C5-C6 spinal segment significantly reduces NWR thresholds in muscles of the upper limb. Upper limb NWR thresholds from 20 young, healthy adults were assessed by applying noxious electrical stimuli to the right index finger and recording muscle activity from the biceps brachii (BI), triceps brachii (TRI), flexor carpi ulnaris (WF), and extensor carpi radialis longus (WE) muscles via surface electromyography. Topical cream (either 0.075% capsaicin, or control) was applied to the C5-C6 dermatome of the lateral forearm (50 cm

Indexed as

CapsaicinNociceptionAdultCentral Nervous System SensitizationElectric StimulationElectromyographyHumansMuscle, SkeletalPain ThresholdReflexReproducibility of ResultsUpper ExtremityCapsaicinCapsaicinCentral sensitizationNociceptive withdrawal reflexUpper limb

Identifiers

PMID34505162
OpenAlexW3197254690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.