Evidence map›Paper›PMID 34504955›Full record

ReviewBiochemistry and biophysics reports2021

Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective "hot" vanilloid compounds and analogs.

Guangyu Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. A journey from molecule to physiology andFrontiers in pharmacology · 2023
    Review
  2. Signaling pathways in cutaneous wound healing.Frontiers in physiology · 2022
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Guangyu WangDepartment of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA, USA.
University of California, Davis · US

Funding

CFTR--ION CONDUCTION AND GATING MECHANISMSR01DK045880 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAWSON, DAVID C · 1992 to 2010
$3.5M
New paradigms of CFTR regulationR56DK056796 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIRK, KEVIN L · 2010 to 2010
$220k
CFTR-Ion Conduction and Gating MechanismsR56DK045880 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAWSON, DAVID C · 2007 to 2007
$57k
NIDDK NIH HHS R01 DK045880NIDDK NIH HHS R56 DK045880NIDDK NIH HHS R56 DK056796
6 · The paper itself

Abstract

Both a silent resident phosphatidylinositol lipid and a "hot" vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. However, how the vanilloid competes off the resident lipid for allosteric TRPV1 activation is unknown. Here, the

Indexed as

Active site stereoselectivityDominant steady-state ligand bindingHydrogen bonding networkIon channelLipid-ligand interactionRecessive transient ligand bindingSequential cooperativity

Identifiers

PMID34504955
PMCPMC8416642
OpenAlexW3197825200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.