Evidence map›Paper›PMID 34504932›Full record

ArticleGynecologic oncology reports2021

Discordant immunohistochemistry in an unusual MLH1 gene variant in a case of Lynch syndrome.

Prerana Nagabhushana, Snigdha Kumari, Minakshi Rohilla, Radhika Srinivasan, Aashima Arora, Pulkit Rastogi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Prerana NagabhushanaDepartment of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
Snigdha KumariDepartment of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
Minakshi RohillaDepartment of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
Radhika SrinivasanDepartment of Cytology and Gynecologic Pathology, PGIMER, Chandigarh, India.
Aashima AroraDepartment of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
Pulkit RastogiDepartment of Histopathology, PGIMER, Chandigarh, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunohistochemistry for mismatch repair proteins and microsatellite instability testing are recommended screening methods for Lynch syndrome. They have a good sensitivity and specificity, allowing for directed genetic testing and diagnosis. We report a case of Lynch syndrome with retained MMR protein expression who later showed an

Indexed as

Endometrial cancerImmunohistochemistryLynch syndromeMismatch repair proteinMLH1

Identifiers

PMID34504932
PMCPMC8416636
OpenAlexW3196418363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.