Evidence map›Paper›PMID 34504802›Full record

ArticleFrontiers in oncology2021

Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect.

Umair Majeed, Tudor Puiu, Jason Sluzevich, Gina Reynolds, Marites Acampora, Alvaro Moreno-Aspitia, Katherine J Bodiford, Pooja Advani

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Umair MajeedDivision of Hematology Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.
Tudor PuiuDivision of Dermatology, Mayo Clinic Florida, Jacksonville, FL, United States.
Jason SluzevichDivision of Dermatology, Mayo Clinic Florida, Jacksonville, FL, United States.
Gina ReynoldsDivision of Hematology Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.
Marites AcamporaDivision of Hematology Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.
Alvaro Moreno-AspitiaDivision of Hematology Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.
Katherine J BodifordDivision of Dermatology, Mayo Clinic Florida, Jacksonville, FL, United States.
Pooja AdvaniDivision of Hematology Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.
Mayo Clinic in Florida · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpelisib is a PIK3a inhibitor approved for the treatment of metastatic ER+ breast cancer in combination with fulvestrant. Although rash is a common side effect of this medication, we present the first case of drug reaction with eosinophilia and systemic symptoms (DRESS) upon initial exposure to alpelisib. Here we describe the clinical-pathological findings and management of our patient with alpelisib-induced life-threatening DRESS syndrome. The goal of this case report is to highlight association of alpelisib with DRESS syndrome, in clinical practice, so that alpelisib can be immediately stopped and treatment for this serious condition promptly initiated.

Indexed as

alpelisibbreast cancerDRESSdrug rashPI3K inhibitor therapy

Identifiers

PMID34504802
PMCPMC8421674
OpenAlexW3195291295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.