ArticlePsychology & neuroscience2020
The role of the ventromedial prefrontal cortex and context in regulating fear learning and extinction.
Article in Psychology & neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Menstrual Cycle Informed Psychotherapy: Preliminary Findings in Women with Spider Phobia.Psychotherapy and psychosomatics · 2026Article
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear.Psychopharmacology · 2025Article
- A biopsychosocial model of MDMA-assisted therapy in application: Dyadic One Session Treatment for specific phobia.Frontiers in psychiatry · 2025Article
- Subregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety.PLoS biology · 2025Article
- Regional prefrontal and hippocampal differences in gray matter volume are linked to the propensity for renewal in extinction learning.Frontiers in behavioral neuroscience · 2025Article
- Adaptive Safety Coding in the Prefrontal Cortex.bioRxiv : the preprint server for biology · 2024Article
- The Neuronal Hypofunction of Subdivisions of the Prefrontal Cortex Shows Differential Effects on Contingency Judgment Learning to Gauge Fear Responses.Neuroscience insights · 2024Article
- A Ventromedial Prefrontal-to-Lateral Entorhinal Cortex Pathway Modulates the Gain of Behavioral Responding During Threat.Biological psychiatry · 2023Article
- Absence of modulatory effects of 6Hz cerebellar transcranial alternating current stimulation on fear learning in men.Frontiers in human neuroscience · 2023Article
- Multiplexed Membrane Signaling by Glucocorticoids.Current opinion in endocrine and metabolic research · 2022Article
- Neural Circuits Underlying Social Fear in Rodents: An Integrative Computational Model.Frontiers in systems neuroscience · 2022Article
- A Decision Architecture for Safety Computations.Trends in cognitive sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
An organism's ability to learn about and respond to stimuli in its environment is crucial for survival, which can involve learning simple associations such as learning what stimuli predict danger. However, individuals must also be able to use contextual information to adapt to changing environmental demands. While the circuitry that supports fear conditioning has been extensively studied, the circuitry that allows individuals to regulate fear under different circumstance is less well understood. A view of ventromedial prefrontal cortex (vmPFC) function has emerged wherein the prelimbic region of the vmPFC supports fear expression, while the infralimbic region supports fear inhibition. However, despite a rich literature exploring the role of these regions in appetitive learning and memory suggesting a more nuanced function, there has been little integration of this literature with studies of the vmPFC in fear learning. In this review, we argue that the function of the vmPFC in fear learning is not restricted to fear inhibition versus expression
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.