Evidence map›Paper›PMID 34504470›Full record

ArticleFrontiers in endocrinology2021

Vasopressinergic Activity of the Suprachiasmatic Nucleus and mRNA Expression of Clock Genes in the Hypothalamus-Pituitary-Gonadal Axis in Female Aging.

Angela Cristina Nicola, Larissa Brazoloto Ferreira, Milene Mantovani Mata, Tatiane Vilhena-Franco, Cristiane Mota Leite, Andressa Busetti Martins, José Antunes-Rodrigues, Maristela Oliveira Poletini, Rita Cássia Menegati Dornelles

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Age-related changes in diurnal expression of inflammatory mediators in the brain and peripheral blood of male and female mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Angela Cristina NicolaPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis/UNESP, Department of Basic Sciences, Araçatuba, Brazil.
Larissa Brazoloto FerreiraPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis/UNESP, Department of Basic Sciences, Araçatuba, Brazil.
Milene Mantovani MataUniversity of Sao Paulo (USP), School of Medicine of Ribeirão Preto, Department of Physiology, Ribeirão Preto, Brazil.
Tatiane Vilhena-FrancoUniversity of Sao Paulo (USP), School of Medicine of Ribeirão Preto, Department of Physiology, Ribeirão Preto, Brazil.
Cristiane Mota LeiteUniversity of Northern Paraná (UNOPAR), Londrina, Brazil.
Andressa Busetti MartinsPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis/UEL, Department of Physiological Sciences, Londrina, Brazil.
José Antunes-RodriguesUniversity of Sao Paulo (USP), School of Medicine of Ribeirão Preto, Department of Physiology, Ribeirão Preto, Brazil.
Maristela Oliveira PoletiniFederal University of Minas Gerais (UFMG), Institute of Biological Sciences, Department of Physiology and Biophysics, Belo Horizonte, Brazil.
Rita Cássia Menegati DornellesPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis/UNESP, Department of Basic Sciences, Araçatuba, Brazil.
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de Minas Gerais · BRUniversidade Norte do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The important involvement of the suprachiasmatic nucleus (SCN) and the activity of vasopressinergic neurons in maintaining the rhythmicity of the female reproductive system depends on the mRNA transcription-translation feedback loops. Therefore, circadian clock function, like most physiological processes, is involved in the events that determine reproductive aging. This study describes the change of mRNA expression of clock genes,

Indexed as

AgingCircadian RhythmAnimalsARNTL Transcription FactorsCircadian ClocksFemaleGonadsHypothalamo-Hypophyseal SystemNuclear Receptor Subfamily 1, Group D, Member 1Period Circadian ProteinsRatsRats, WistarRNA, MessengerSuprachiasmatic NucleusVasopressinsArntl protein, ratARNTL Transcription FactorsNr1d1 protein, ratNuclear Receptor Subfamily 1, Group D, Member 1Per2 protein, ratPeriod Circadian ProteinsRNA, MessengerVasopressinsagingclock geneshypothalamus-pituitary-gonadal axiskisspeptinsuprachiasmatic nucleusvasopressin

Identifiers

PMID34504470
PMCPMC8421860
OpenAlexW3194371188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.