Evidence map›Paper›PMID 34504446›Full record

ArticleFrontiers in psychiatry2021

A Phase II Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Arbaclofen Administered for the Treatment of Social Function in Children and Adolescents With Autism Spectrum Disorders: Study Protocol for AIMS-2-TRIALS-CT1.

Mara Parellada, Antonia San José Cáceres, Melanie Palmer, Richard Delorme, Emily J H Jones, Jeremy R Parr, Evdokia Anagnostou, Declan G M Murphy, Eva Loth, Paul P Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Mara ParelladaInstitute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Antonia San José CáceresInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Melanie PalmerDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Richard DelormeChild and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, Paris, France.
Emily J H JonesCentre of Brain and Cognitive Development, Birkbeck College, London, United Kingdom.
Jeremy R ParrPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Evdokia AnagnostouDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Declan G M MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Eva LothDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Paul P WangClinical Research Associates LLC, New York, NY, United States.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Andre StrydomDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Celso ArangoInstitute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
King's College London · GBCentro de Investigación Biomédica en Red de Salud Mental · ESAssistance Publique – Hôpitaux de Paris · FRBirkbeck, University of London · GBClinical Research Associates · USGreat North Children's Hospital · GBHospital General Universitario Gregorio Marañón · ESUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adolescentarbaclofenautismchildrenrandomized controlled trialsocial function

Identifiers

PMID34504446
PMCPMC8421761
OpenAlexW3193354979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.