Evidence map›Paper›PMID 34504437›Full record

ArticleFrontiers in physiology2021

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization.

Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Mechanosensitive Piezo1 Channels in Enamel Cells.Calcified tissue international · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Injectable Piezoelectric Hydrogel for Vital Pulp Therapy.Journal of functional biomaterials · 2025
    Article
  13. Review
  14. Article
  15. Intracellular cAMP signaling-induced CaPflugers Archiv : European journal of physiology · 2025
    Article
  16. Review
  17. TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Pharmacology of PIEZO1 channels.British journal of pharmacology · 2024
    Review
  19. Dentin Mechanobiology: Bridging the Gap between Architecture and Function.International journal of molecular sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mayumi MatsunagaDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Maki KimuraDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Takehito OuchiDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Takashi NakamuraDepartment of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Sadao OhyamaDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Masayuki AndoDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Sachie NomuraDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Toshifumi AzumaDepartment of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Tatsuya IchinoheDepartment of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Yoshiyuki ShibukawaDepartment of Physiology, Tokyo Dental College, Tokyo, Japan.
Tokyo Dental College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in cellular deformation. Recently, Piezo1 channels have been implicated in mechanosensitive processes, as well as Ca

Indexed as

dentinmechanosensitive channelodontoblastorofacial painPiezo channeltooth pain

Identifiers

PMID34504437
PMCPMC8421527
OpenAlexW3195416274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.