ArticleJNMA; journal of the Nepal Medical Association2020
Knuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report.
Article in JNMA; journal of the Nepal Medical Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Pernicious Anemia: A Rare Case of Vitamin B12 Deficiency With Hyperpigmentation and Pancytopenia.Case reports in medicine · 2026Article
- Asymmetric darkened knuckles with subclinical myopathy revealed anti-Mi2b positive dermatomyositis.Clinical rheumatology · 2024Article
- Article
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2 authors at 1 institution.
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Abstract
Vitamin B12 deficiency can present with variable hematological, neuropsychiatric, and mucocutaneous changes. Hyperpigmentation, specifically involving the knuckles has been described in vitamin B12 deficiency, but usually,these patients are symptomatic with systemic manifestations like megaloblastic anemia, pancytopenia, or neurological deficits. Here, we are reporting a case of nutritional vitamin B12 deficiency, who presented with isolated knuckle pigmentation and was successfully treated with oral therapy. This case also highlights the importance of recognizing this cutaneous sign as an early marker of vitamin B12 deficiency; thereby enabling the clinician to treat the disease before it leads to irreversible neurological complications. Keywords: knuckle pigmentation;treatment;vitamin B12 deficiency.
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