ArticleScientific reports2021
Analysis of pupillometer results according to disease stage in patients with Parkinson's disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Pupil-light reflex in early-stage Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Participants' characteristics influencing pupillometry parameters in a community in Japan.Fukushima journal of medical science · 2026Article
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Longitudinal analysis of pupillometry according to type of pharmacotherapy in Parkinson's disease patients.Scientific reports · 2025Article
- Evaluation of autonomic involvement in Parkinson's disease using pupillometry.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Pupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's disease.BMC ophthalmology · 2025Article
- Non-motor asymmetry and dopamine degeneration in Parkinson's disease.Brain communications · 2025Article
- Improving Eye-Tracking Data Quality: A Framework for Reproducible Evaluation of Detection Algorithms.Sensors (Basel, Switzerland) · 2024Article
- Nonlinear Regression Modelling: A Primer with Applications and Caveats.Bulletin of mathematical biology · 2024Article
- The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review.Journal of clinical medicine · 2024Review
- Comparison of an AI-based mobile pupillometry system and NPi-200 for pupillary light reflex and correlation with glaucoma-related markers.Frontiers in neurology · 2024Article
- Visual Dysfunction in Parkinson's Disease.Brain sciences · 2023Review
- Pupillometry to Assess Auditory Sensation in Guinea Pigs.Journal of visualized experiments : JoVE · 2023Article
- Pupil light reflex dynamics in Parkinson's disease.Frontiers in integrative neuroscience · 2023Article
- Do static and dynamic pupillary parameters differ according to childhood, adulthood, and old age? A quantitative study in healthy volunteers.Indian journal of ophthalmology · 2022Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed pupillometer testing on 132 patients with Parkinson's disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and patients in stages 3-5 formed the late group. We performed age- and sex-matched (2:1) propensity score matching to compensate for the effect of age on pupil light reflex. Eight pupillometer parameters were measured and compared between the two groups. After the propensity score matching, the early group had 64 patients and the late group had 32 patients. The late group had a longer disease duration and took a higher levodopa equivalent dose than the early group. The constriction velocity (P = 0.006) and maximum constriction velocity (P = 0.005) were significantly faster in the early group than in the late group. Pupil size, minimum diameter, and dilation velocity were similar in both groups. The pupillary contraction velocity decreased with the disease progression, suggesting that the progression of Parkinson's disease could be identified by the pupil constriction velocity.
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