Evidence map›Paper›PMID 34504188›Full record

ArticleScientific reports2021

Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults.

Julia J Yudkovicz, Ryan L Minster, Emma Barinas-Mitchell, Kaare Christensen, Mary Feitosa, Megan S Barker, Anne B Newman, Allison L Kuipers

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Julia J YudkoviczDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Emma Barinas-MitchellDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Kaare ChristensenDepartment of Epidemiology, Biostatistics and Biodemography, Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark.
Mary FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Megan S BarkerDepartment of Neurology, Columbia University, New York, NY, USA.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Allison L KuipersDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. kuipers@pitt.edu.
University of Pittsburgh · USColumbia University · USUniversity of Southern Denmark · DK

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI PAOLA SEBASTIANI · 2019 to 2026
$125.4M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
The Long Life Family StudyU01AG023755 · NIA · BOSTON MEDICAL CENTER · PI PERLS, THOMAS T · 2004 to 2018
$13.2M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Multicenter Study on Exceptional Survival in Families: The Long Life Family StudyU01AG023744 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B., ZMUDA, JOSEPH M. · 2004 to 2018
$12.0M
Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field CenterU01AG023712 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2004 to 2018
$10.4M
Molecular Epidemiology of the Wnt Pathway in Subclinical Cardiovascular DiseaseK01HL125658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KUIPERS, ALLISON L · 2015 to 2019
$693k
NHLBI NIH HHS K01 HL125658NIA NIH HHS U01 AG023712NIA NIH HHS U01 AG023744NIA NIH HHS U01 AG023746NIA NIH HHS U01 AG023749NIA NIH HHS U01 AG023755NIA NIH HHS U19 AG063893
6 · The paper itself

Abstract

Cardiovacular disease (CVD) is the leading cause of death among older adults and is often accompanied by functional decline. It is unclear what is driving this co-occurrence, but it may be behavioral, environmental and/or genetic. We used a family-based study to estimate the phenotypic and shared genetic correlation between CVD risk factors and physical and cognitive functional measures. Participants (n = 1,881) were from the Long Life Family Study, which enrolled families based on their exceptional longevity (sample mean age = 69.4 years, 44% female). Cardiovascular disease risk factors included carotid vessel measures [intima-media thickness and inter-adventitial diameter], obesity [body mass index (BMI) and waist circumference], and hypertension [systolic and diastolic blood pressures]. Function was measured in the physical [gait speed, grip strength, chair stand] and cognitive [digital symbol substitution test, retained and working memory, semantic fluency, and trail making tests] domains. We used SOLAR to estimate the genetic, environmental, and phenotypic correlation between each pair adjusting for age, age

Indexed as

CognitionFamilyGenetic PleiotropyPhysical Functional PerformanceAgedAged, 80 and overBlood PressureBody Mass IndexCardiovascular DiseasesCarotid Intima-Media ThicknessCohort StudiesComorbidityDenmarkFemaleHumansHypertension

Identifiers

PMID34504188
PMCPMC8429644
OpenAlexW3198758579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.