Evidence map›Paper›PMID 34504186›Full record

ArticleScientific reports2021

Sequencing and characterization of an L-asparaginase gene from a new species of Penicillium section Citrina isolated from Cerrado.

Kellen C R Andrade, Rildo A Fernandes, Danilo Batista Pinho, Marcela M de Freitas, Edivaldo Ximenes Ferreira Filho, Adalberto Pessoa, João Inácio Silva, Perola O Magalhães

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Three New Species ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  4. A Structural In Silico Analysis of the Immunogenicity of L-Asparaginase fromInternational journal of molecular sciences · 2024
    Article
  5. A review of recently introducedStudies in mycology · 2024
    Article
  6. Article
  7. Review
  8. Species Diversity ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Cacti as low-cost substrates to produce L-asparaginase by endophytic fungi.World journal of microbiology & biotechnology · 2022
    Article
  11. L-Asparaginase fromPharmaceuticals (Basel, Switzerland) · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kellen C R AndradeLaboratory of Natural Products, Department of Pharmacy, Health Sciences School, University of Brasilia, Brasilia, Brazil.
Rildo A FernandesMycology Laboratory, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
Danilo Batista PinhoMycology Laboratory, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
Marcela M de FreitasLaboratory of Natural Products, Department of Pharmacy, Health Sciences School, University of Brasilia, Brasilia, Brazil.
Edivaldo Ximenes Ferreira FilhoEnzymology Laboratory, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
Adalberto PessoaDepartment of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
João Inácio SilvaSchool of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
Perola O MagalhãesLaboratory of Natural Products, Department of Pharmacy, Health Sciences School, University of Brasilia, Brasilia, Brazil. perolamagalhaes@unb.br.
Universidade de Brasília · BRUniversidade de São Paulo · BRUniversity of Brighton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme L-asparaginase (L-ASNase) is used in the treatment of Acute Lymphoblastic Leukemia. The preparations of this enzyme for clinical use are derived from bacterial sources and its use is associated with serious adverse reactions. In this context, it is important to find new sources of L-ASNase. In this work, the Placket-Burman Experimental Design (PBD) was used to determine the influence of the variables on the L-ASNase production then it was followed by a 2

Indexed as

Antineoplastic AgentsAsparaginaseHumansPenicilliumPrecursor Cell Lymphoblastic Leukemia-LymphomaProlineSequence Analysis, DNAAntineoplastic AgentsAsparaginaseProline

Identifiers

PMID34504186
PMCPMC8429440
OpenAlexW3196744022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.