ArticleScientific reports2021
Effects of radiation damage and inelastic scattering on single-particle imaging of hydrated proteins with an X-ray Free-Electron Laser.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Impact of gas background on XFEL single-particle imaging.Scientific reports · 2025Article
- X-ray radiation damage cycle of solvated inorganic ions.Nature communications · 2024Article
- Computational study of diffraction image formation from XFEL irradiated single ribosome molecule.Scientific reports · 2024Article
- A phenomenological model of the X-ray pulse statistics of a high-repetition-rate X-ray free-electron laser.IUCrJ · 2023Article
- Water layer and radiation damage effects on the orientation recovery of proteins in single-particle imaging at an X-ray free-electron laser.Scientific reports · 2023Article
- Expected resolution limits of x-ray free-electron laser single-particle imaging for realistic source and detector properties.Structural dynamics (Melville, N.Y.) · 2022Article
- Tree-Code Based Improvement of Computational Performance of the X-ray-Matter-Interaction Simulation Tool XMDYN.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a computational case study of X-ray single-particle imaging of hydrated proteins on an example of 2-Nitrogenase-Iron protein covered with water layers of various thickness, using a start-to-end simulation platform and experimental parameters of the SPB/SFX instrument at the European X-ray Free-Electron Laser facility. The simulations identify an optimal thickness of the water layer at which the effective resolution for imaging the hydrated sample becomes significantly higher than for the non-hydrated sample. This effect is lost when the water layer becomes too thick. Even though the detailed results presented pertain to the specific sample studied, the trends which we identify should also hold in a general case. We expect these findings will guide future single-particle imaging experiments using hydrated proteins.
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