Evidence map›Paper›PMID 34504116›Full record

ArticleScientific reports2021

Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice.

Fatemeh Ashrafian, Shahrbanoo Keshavarz Azizi Raftar, Arefeh Shahryari, Ava Behrouzi, Rezvan Yaghoubfar, Arezou Lari, Hamid Reza Moradi, Shohreh Khatami, Mir Davood Omrani, Farzam Vaziri and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Foods (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Big lessons from the littleFrontiers in immunology · 2025
    Review
  18. Article
  19. Review
  20. Frontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Fatemeh Ashrafian *Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Shahrbanoo Keshavarz Azizi Raftar *Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Arefeh ShahryariMicrobiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Ava BehrouziMicrobiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Rezvan YaghoubfarMicrobiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Arezou LariSystems Biomedicine Unit, Pasteur Institute of Iran, Tehran, Iran.
Hamid Reza MoradiDepartment of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Shohreh KhatamiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Mir Davood OmraniDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farzam VaziriMicrobiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Andrea MasottiResearch Laboratories, Children's Hospital Bambino Gesù-IRCCS, Rome, Italy.
Seyed Davar SiadatMicrobiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. d.siadat@gmail.com.ORCID http://orcid.org/0000-0002-7288-8112
Pasteur Institute of Iran · IRBambino Gesù Children's Hospital · ITShahid Beheshti University of Medical Sciences · IRShiraz University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, Akkermansia muciniphila an anaerobic member of the gut microbiota, has been proposed as a next-generation probiotic. The aim of this study was evaluation of the effect of alive and pasteurized A. muciniphila on health status, intestinal integrity, immune response, lipid metabolism, and gut microbial composition in normal-diet fed mice as well as direct effects of the bacterium on Caco-2 cell line. A total of 30 mice were distributed into three different groups, control, alive, and pasteurized A. muciniphila-treated group. After acclimation, control and treatment groups were administrated with PBS and 10

Indexed as

AkkermansiaAnimalsCaco-2 CellsGastrointestinal MicrobiomeHomeostasisHumansLipid MetabolismMiceProbiotics

Identifiers

PMID34504116
PMCPMC8429653
OpenAlexW3196639218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.