Evidence map›Paper›PMID 34504050›Full record

ArticleMolecules and cells2021

Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression.

Jie Guo, Mengfan Liao, Xianmin Hu, Jun Wang

Open access · diamondAbstract read
In one paragraph

Article in Molecules and cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Bioinformatics analysis revealsTranslational cancer research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jie GuoHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0002-0645-3321
Mengfan LiaoHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0002-5140-8669
Xianmin HuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0003-1258-3859
Jun WangHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0002-1679-1922
Wuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an

Indexed as

AnimalsCell Line, TumorDendritic CellsDisease Models, AnimalDisease ProgressionFemaleHeterograftsHumansMiceMice, SCIDPancreatic NeoplasmsPancreatitis-Associated ProteinsPancreatitis-Associated ProteinsREG3A protein, humandendritic cellsimmunosuppressive tumour microenvironmentinflammation-linked pancreatic carcinogenesispancreatic cancerregenerating islet-derived protein 3A

Identifiers

PMID34504050
PMCPMC8490200
OpenAlexW3198007497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.