Evidence map›Paper›PMID 34503999›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Comparative genomics provides insights into the aquatic adaptations of mammals.

Yuan Yuan, Yaolei Zhang, Peijun Zhang, Chang Liu, Jiahao Wang, Haiyu Gao, A Rus Hoelzel, Inge Seim, Meiqi Lv, Mingli Lin and 31 more

Abstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The genetic foundations of convergent traits.Nature reviews. Genetics · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Near-Telomere-to-Telomere Genome Assembly of the Spotted Seal (International journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A phylogenetic approach to comparative genomics.Nature reviews. Genetics · 2025
    Review
  18. Article
  19. Article
  20. Reference genome of the leopard seal (Frontiers in genetics · 2025
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Yuan YuanMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Yaolei ZhangBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.ORCID 0000-0003-2131-0254
Peijun ZhangMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Chang LiuSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710072, China.
Jiahao WangBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Haiyu GaoMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
A Rus HoelzelDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.ORCID 0000-0002-7265-4180
Inge SeimIntegrative Biology Laboratory, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.ORCID 0000-0001-8594-7217
Meiqi LvBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Mingli LinMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Lijun DongMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Haoyang GaoBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Zixin YangMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Francesco CarusoMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Wenzhi LinMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Rute R da FonsecaCenter for Macroecology, Evolution, and Climate, GLOBE Institute, University of Copenhagen, 1165 Copenhagen, Denmark.ORCID 0000-0002-2805-4698
Ding WangKey Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.ORCID 0000-0001-5867-2035
Xianyan WangLaboratory of Marine Biology and Ecology, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
Marianne H RasmussenResearch Center in Húsavík, University of Iceland, Húsavík 640, Iceland.ORCID 0000-0002-6887-8616
Mingming LiuMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Jinsong ZhengKey Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Liyuan ZhaoLaboratory of Marine Biology and Ecology, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
Paula F CamposInterdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos 4450-208, Portugal.ORCID 0000-0003-1285-4671
Hui KangMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.
Maria IversenResearch Center in Húsavík, University of Iceland, Húsavík 640, Iceland.ORCID 0000-0003-2708-8068
Yue SongBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Xinyu GuoBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Jiao GuoBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Yating QinBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Shanshan PanBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Qiwu XuBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Lingfeng MengBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.ORCID 0000-0001-9051-0992
Yunga ABGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Shanshan LiuBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Simon Ming-Yuen LeeState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
Xin LiuBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Xun XuBGI-Shenzhen, Shenzhen 518083, China.
Huanming YangBGI-Shenzhen, Shenzhen 518083, China.
Guangyi FanBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China; lish@idsse.ac.cn wangkun@nwpu.edu.cn fanguangyi@genomics.cn.
Kun WangSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710072, China; lish@idsse.ac.cn wangkun@nwpu.edu.cn fanguangyi@genomics.cn.
Songhai LiMarine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China; lish@idsse.ac.cn wangkun@nwpu.edu.cn fanguangyi@genomics.cn.ORCID 0000-0003-4977-1722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (

Indexed as

Adaptation, PhysiologicalEvolution, MolecularGenomeGenomicsPhylogenyAnimalsMammalsNFI Transcription FactorsSelection, GeneticSemaphorinsThermogenesisUncoupling Protein 1NFI Transcription FactorsSemaphorinsUncoupling Protein 1aquatic adaptationcomparative genomicsmarine mammals

Identifiers

PMID34503999
PMCPMC8449357

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.