Evidence map›Paper›PMID 34503958›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Harnessing

Hua Yang, Justin J Wilson, Chris Orvig, Yawen Li, D Scott Wilbur, Caterina F Ramogida, Valery Radchenko, Paul Schaffer

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Predicting tumour and organ dose in α-radiopharmaceutical therapy: aEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. High-Yield Room-Temperature ArylACS organic & inorganic Au · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Preclinical characterization of 3p-C-DEPAEJNMMI radiopharmacy and chemistry · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. EJNMMI radiopharmacy and chemistry · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody.Journal of cancer research and clinical oncology · 2025
    Article
  19. Towards DFO*Pharmaceutics · 2025
    Article
  20. Current landscape and clinical progress of targeted alpha radioimmunotherapy.American journal of nuclear medicine and molecular imaging · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hua YangLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada; hyang@triumf.ca.
Justin J WilsonChemistry and Chemical Biology, Cornell University, Ithaca, New York.
Chris OrvigMedicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Yawen LiDepartment of Radiation Oncology, University of Washington, Seattle, Washington.
D Scott WilburDepartment of Radiation Oncology, University of Washington, Seattle, Washington.
Caterina F RamogidaLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada.
Valery RadchenkoLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada.
Paul SchafferLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada.

Funding

Chelation strategies for s-, p-, and f-block radionuclides for targeted alpha therapyR01EB029259 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2020 to 2023
$1.4M
Expanding the Therapeutic Potential of the Alpha Emitter Radium-223R21EB027282 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2019 to 2021
$619k
NIBIB NIH HHS R01 EB029259NIBIB NIH HHS R21 EB027282
6 · The paper itself

Abstract

Targeted α-therapy (TAT) is an emerging powerful tool treating late-stage cancers for which therapeutic options are limited. At the core of TAT are targeted radiopharmaceuticals, where isotopes are paired with targeting vectors to enable tissue- or cell-specific delivery of α-emitters. DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and DTPA (diethylenetriamine pentaacetic acid) are commonly used to chelate metallic radionuclides but have limitations. Significant efforts are underway to develop effective stable chelators for α-emitters and are at various stages of development and community adoption. Isotopes such as

Indexed as

Chelating AgentsIsotope LabelingNanoparticle Drug Delivery SystemRadioisotopesRadiopharmaceuticalsTheranostic NanomedicineAnimalsHeterocyclic Compounds, 1-RingHumansNeoplasmsNeoplasm StagingPentetic AcidTumor Microenvironment1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidChelating AgentsHeterocyclic Compounds, 1-RingNanoparticle Drug Delivery SystemPentetic AcidRadioisotopesRadiopharmaceuticalschelationradiolabelingreviewtargeted α-therapyα-emitter

Identifiers

PMID34503958
PMCPMC8717181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.