Evidence map›Paper›PMID 34503943›Full record

ArticleAJNR. American journal of neuroradiology2021

Alterations in the Magnetoencephalography Default Mode Effective Connectivity following Concussion.

D D Reddy, E M Davenport, F F Yu, B Wagner, J E Urban, C T Whitlow, J D Stitzel, J A Maldjian

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D D ReddyFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas divya.reddy@utsouthwestern.edu.ORCID 0000-0001-5899-0981
E M DavenportFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas.ORCID 0000-0002-8765-6584
F F YuFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas.ORCID 0000-0001-9913-1331
B WagnerFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas.ORCID 0000-0003-2835-986X
J E UrbanWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina.ORCID 0000-0002-7348-9244
C T WhitlowWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina.ORCID 0000-0003-2392-8293
J D StitzelWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina.ORCID 0000-0001-9762-3033
J A MaldjianFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas divya.reddy@utsouthwestern.edu.ORCID 0000-0002-6384-1072

Funding

iTAKL: Imaging Telemetry And Kinematic modeLing in youth footballR01NS082453 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GIOIA, GERARD A., MALDJIAN, JOSEPH A · 2014 to 2018
$3.3M
iTAKL:Imaging Telemetry And Kinematic modeLing in youth football-High SchoolR01NS091602 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MALDJIAN, JOSEPH A, STITZEL, JOEL DOUGLAS · 2016 to 2020
$3.2M
NINDS NIH HHS R01 NS082453NINDS NIH HHS R01 NS091602
6 · The paper itself

Abstract

background and purposeMagnetoencephalography is sensitive to functional connectivity changes associated with concussion. However, the directional influences between functionally related regions remain unexplored. In this study, we therefore evaluated concussion-related magnetoencephalography-based effective connectivity changes within resting-state default mode network regions. MATERIALS AND

methodsResting-state magnetoencephalography was acquired for 8 high school football players with concussion at 3 time points (preseason, postconcussion, postseason), as well as 8 high school football players without concussion and 8 age-matched controls at 2 time points (preseason, postseason). Time-series from the default mode network regions were extracted, and effective connectivity between them was computed for 5 different frequency bands. The default mode network regions were grouped into anterior and posterior default mode networks. The combined posterior-to-anterior and anterior-to-posterior effective connectivity values were averaged to generate 2 sets of values for each subject. The effective connectivity values were compared using a repeated measures ANOVA across time points for the concussed, nonconcussed, and control groups, separately.

resultsA significant increase in posterior-to-anterior effective connectivity from preseason to postconcussion (corrected

conclusionsThe unidirectional increase in effective connectivity postconcussion may elucidate compensatory processes, invoking use of posterior regions to aid the function of susceptible anterior regions following brain injury. These findings support the potential value of magnetoencephalography in exploring directional changes of the brain network following concussion.

Indexed as

Brain ConcussionFootballBrainBrain MappingHumansMagnetic Resonance ImagingMagnetoencephalography

Identifiers

PMID34503943
PMCPMC8562757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.