Evidence map›Paper›PMID 34503684›Full record

ReviewJournal of the American College of Cardiology2021

Medial Arterial Calcification: JACC State-of-the-Art Review.

Peter Lanzer, Fadil M Hannan, Jan D Lanzer, Jan Janzen, Paolo Raggi, Dominic Furniss, Mirjam Schuchardt, Rajesh Thakker, Pak-Wing Fok, Julio Saez-Rodriguez and 5 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 10 pooled it
33.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 10 syntheses or guidelines pooled it, 312 citations in OpenAlex.

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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 6 countries.

Peter LanzerMiddle German Heart Center-Bitterfeld, Bitterfeld-Wolfen Health Care Center, Bitterfeld, Germany. Electronic address: lanzer.peter@web.de.
Fadil M HannanNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.
Jan D LanzerInstitute for Computational Biomedicine, Bioquant, Faculty of Medicine, Heidelberg University, Heidelberg, Germany; Department of Internal Medicine II, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Heidelberg, Germany.
Jan JanzenVascPath Switzerland, Bern, Switzerland.
Paolo RaggiDivision of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Dominic FurnissBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Mirjam SchuchardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität and Humboldt Universität Berlin, Campus Benjamin Franklin, Berlin, Germany.
Rajesh ThakkerAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Pak-Wing FokDepartment of Mathematical Sciences, University of Delaware, Newark, Delaware, USA.
Julio Saez-RodriguezInstitute for Computational Biomedicine, Bioquant, Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
Angel MillanInstitute of Materials Science, University of Zaragoza, Zaragoza, Spain.
Yu SatoCVPath Institute, Gaithersburg, Maryland, USA.
Roberto FerraresiCardiovascular Department, Humanitas Gavazzeni, Bergamo, Italy.
Renu VirmaniCVPath Institute, Gaithersburg, Maryland, USA.
Cynthia St HilaireDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
CVPath Institute · USHeidelberg University · DEUniversity of Oxford · GBGesundheitszentrum Bitterfeld · DEHumanitas Gavazzeni · ITHumboldt-Universität zu Berlin · DEInstituto de Ciencia de Materiales de Sevilla · ESNuffield Orthopaedic Centre · GBUniversity of Alberta · CAUniversity of Delaware · USUniversity of Pittsburgh · US

Funding

The Role of Telomerase in Calcific Aortic Valve DiseaseR01HL142932 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST. HILAIRE, CYNTHIA · 2018 to 2022
$2.3M
Regulation of Vascular Calcification by Adenosine SignalingK22HL117917 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST. HILAIRE, CYNTHIA · 2015 to 2017
$731k
Department of HealthNHLBI NIH HHS K22 HL117917NHLBI NIH HHS R01 HL142932Wellcome Trust
6 · The paper itself

Abstract

Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic kidney disease, and aging. MAC is also a part of more complex phenotypes in numerous less common diseases. The hallmarks of MAC include disseminated and progressive precipitation of calcium phosphate within the medial layer, a prolonged and clinically silent course, and compromise of hemodynamics associated with chronic limb-threatening ischemia. MAC increases the risk of complications during vascular interventions and mitigates their outcomes. With the exception of rare monogenetic defects affecting adenosine triphosphate metabolism, MAC pathogenesis remains unknown, and causal therapy is not available. Implementation of genetics and omics-based approaches in research recognizing the critical importance of calcium phosphate thermodynamics holds promise to unravel MAC molecular pathogenesis and to provide guidance for therapy. The current state of knowledge concerning MAC is reviewed, and future perspectives are outlined.

Indexed as

AnimalsArteriesAtherosclerosisCalcium PhosphatesHumansVascular CalcificationVascular Stiffnesscalcium phosphateCalcium Phosphatesatherosclerosischronic limb-threatening ischemiageneticsmedial arterial calcificationomicsperipheral artery diseasevascular calcification

Identifiers

PMID34503684
PMCPMC8439554
OpenAlexW3197712023

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.