Evidence map›Paper›PMID 34503563›Full record

ArticleTrials2021

Standardised Outcomes in Nephrology - Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy.

Nicole Evangelidis, Benedicte Sautenet, Magdalena Madero, Allison Tong, Gloria Ashuntantang, Laura Cortes Sanabria, Ian H de Boer, Samuel Fung, Daniel Gallego, Andrew S Levey and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Trial
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Five-Year Symptom Trajectories in Nondialysis-Dependent CKD Patients.Clinical journal of the American Society of Nephrology : CJASN · 2022
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 11 countries.

Nicole Evangelidis *Sydney School of Public Health, The University of Sydney, Sydney, Australia. nicole.evangelidis@sydney.edu.au.ORCID http://orcid.org/0000-0001-9184-680X
Benedicte Sautenet *Department of Nephrology, CHU Tours, INSERM SPHERE U1246, University of Tours, University of Nantes, Tours, France.
Magdalena MaderoDivision of Nephrology, Department of Medicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Allison TongSydney School of Public Health, The University of Sydney, Sydney, Australia.
Gloria AshuntantangDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
Laura Cortes SanabriaUnidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Mexico.
Ian H de BoerDepartment of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Samuel FungDivision of Nephrology, Department of Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong, Hong Kong.
Daniel GallegoFederacion Nacional ALCER (Spanish Kidney Patient's Federation), Madrid, Spain.
Andrew S LeveyDivision of Nephrology, Tufts Medical Center, Boston, MA, USA.
Adeera LevinDivision of Nephrology, University of British Columbia, Vancouver, Canada.
Eduardo LorcaDepartment of Nephrology, Hospital Salvador, Santiago, Chile.
Ikechi G OkpechiDivision of Nephrology and Hypertension, University of Cape Town, Cape Town, South Africa.
Patrick RossignolUniversité de Lorraine, Inserm, Centre d'Investigations Clinique 1433 and Inserm U1116; CHRU Nancy; F-CRIN INI-CRCT, Nancy, France.
Laura SolaDialysis Unit, CASMU-IAMPP, Montevideo, Uruguay.
Tim UsherwoodThe University of Sydney, Westmead Clinical School, Westmead, NSW, Australia.
David C WheelerCentre for Nephrology, UCL Medical School, London, UK.
Yeoungjee ChoDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Martin HowellSydney School of Public Health, The University of Sydney, Sydney, Australia.
Chandana GuhaSydney School of Public Health, The University of Sydney, Sydney, Australia.
Nicole Scholes-RobertsonSydney School of Public Health, The University of Sydney, Sydney, Australia.
Katherine WiddersCentre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.
Andrea Matus GonzalezSydney School of Public Health, The University of Sydney, Sydney, Australia.
Armando Teixeira-PintoSydney School of Public Health, The University of Sydney, Sydney, Australia.
Andrea K ViecelliDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Amelie Bernier-JeanSydney School of Public Health, The University of Sydney, Sydney, Australia.
Samaya AnumuduSelzman Institute for Kidney Health, Section of Nephrology, Baylor College of Medicine, Houston, TX, USA.
Louese DunnSheffield Kidney Institute, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Martin WilkieSheffield Kidney Institute, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
SONG-CKD Investigators
The University of Sydney · AUSheffield Teaching Hospitals NHS Foundation Trust · GBBaylor College of Medicine · USChildren's Hospital at Westmead · AUFederación Española de Enfermedades Raras · ESFlinders University · AUHospital del Salvador · CLHospital Universitario de Guadalajara · ESInserm · FRInstituto Nacional de Cardiología · MXPrincess Margaret Hospital · HKThe University of Queensland · AUTranslational Research Institute · AUTufts University · USUniversité de Tours · FRUniversité de Yaoundé I · CMUniversity College London · GBUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Washington · US

Funding

National Health and Medical Research Council 1092597
6 · The paper itself

Abstract

backgroundGlobally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement therapy. The burden of symptoms and impaired quality of life in CKD may be compounded by comorbidities and treatment side effects. However, patient-important outcomes remain inconsistently and infrequently reported in trials in patients with CKD, which can limit evidence-informed decision-making. The Standardised Outcomes in Nephrology - Chronic Kidney Disease (SONG-CKD) aims to establish a consensus-based core outcome set for trials in patients with CKD not yet requiring kidney replacement therapy to ensure outcomes of relevance to patients, caregivers and health professionals are consistently reported in trials.

methodsSONG-CKD involves four phases: a systematic review to identify outcomes (domains and measures) that have been reported in randomised controlled trials involving adults with CKD who do not require kidney replacement therapy; stakeholder key informant interviews with health professionals involved in the care of adults with CKD to ascertain their views on establishing core outcomes in CKD; an international two-round online Delphi survey with patients, caregivers, clinicians, researchers, policy makers and industry representatives to obtain consensus on critically important outcome domains; and stakeholder consensus workshops to review and finalise the set of core outcome domains for trials in CKD. DISCUSSION: Establishing a core outcome set to be reported in trials in patients with CKD will enhance the relevance, transparency and impact of research to improve the lives of people with CKD.

trial registrationNot applicable. This study is registered with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/Studies/Details/1653 .

Indexed as

NephrologyRenal Insufficiency, ChronicAdultDelphi TechniqueHumansOutcome Assessment, Health CareQuality of LifeRenal Replacement TherapyResearch DesignSystematic Reviews as TopicTreatment OutcomeChronic kidney diseaseClinical trialsCore outcome setOutcomes researchPatient-centred outcomes

Identifiers

PMID34503563
PMCPMC8427149
OpenAlexW3196294576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.