Evidence map›Paper›PMID 34503472›Full record

ArticleBMC ophthalmology2021

Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery.

Houfa Yin, Xinyi Chen, Xiaogang Hong, Jian Ma, Fang Wu, Ting Wan, Yiwen Sang, Qiuli Fu, Zhenwei Qin, Danni Lyu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Houfa YinEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xinyi ChenEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaogang HongDepartment of Ophthalmology, People's Hospital of Kaihua, Kaihua, China.
Jian MaEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fang WuEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ting WanEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yiwen SangDepartment of Laboratory Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qiuli FuEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhenwei QinEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Danni LyuEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wei WuEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jinfu YinEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yabo YangEye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. yangyabo@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNPeople's Hospital of Kaizhou District · CN

Funding

Natural Science Foundation of Zhejiang Province LGF19H120003Natural Science Foundation of Zhejiang Province LQ19H120011Program of Zhejiang Medical Technology 2019328715
6 · The paper itself

Abstract

backgroundTo investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery.

methodsTrabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery.

resultsDecellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group.

conclusionsDecellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy.

Indexed as

Filtering SurgeryGlaucomaTrabeculectomyAnimalsConjunctivaDisease Models, AnimalIntraocular PressureRabbitsAdhesion barrierDecellularized lenticuleGlaucomaSMILETrabeculectomy

Identifiers

PMID34503472
PMCPMC8431885
OpenAlexW3160540075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.