Evidence map›Paper›PMID 34503203›Full record

ArticleCancers2021

Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with

Jessica Pahle, Dennis Kobelt, Jutta Aumann, Diana Behrens, Ole Daberkow, Margarita Mokritzkij, Jörg Piontek, Ulrike Stein, Wolfgang Walther

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Type A and DFrontiers in cellular and infection microbiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Non-viral Gene Therapy for Melanoma Using Lysenin from Eisenia Foetida.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Bacterial-Mediated Tumor Therapy: Old Treatment in a New Context.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  15. Claudin and pancreatic cancer.Frontiers in oncology · 2023
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jessica PahleExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Dennis KobeltExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.ORCID 0000-0002-9373-0648
Jutta AumannExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Diana BehrensExperimental Pharmacology & Oncology (EPO) GmbH Berlin-Buch, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Ole DaberkowExperimental Pharmacology & Oncology (EPO) GmbH Berlin-Buch, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Margarita MokritzkijExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Jörg PiontekNutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology, Rheumatology, Institute of Clinical Physiology, Charitè-Universitätsmedizin Berlin, 12203 Berlin, Germany.ORCID 0000-0002-0880-8915
Ulrike SteinExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.ORCID 0000-0001-7006-282X
Wolfgang WaltherExperimental and Clinical Research Center, Charitè-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Max Delbrück Center · DECharité - Universitätsmedizin Berlin · DE

Funding

Deutsche Krebshilfe DKH 110838
6 · The paper itself

Abstract

Pancreatic cancer (PC) is one of the most lethal cancers worldwide, associated with poor prognosis and restricted therapeutic options.

Indexed as

Clostridium perfringens enterotoxin (CPE)combination therapygene therapypancreatic cancersuicide gene

Identifiers

PMID34503203
PMCPMC8431234
OpenAlexW3198675686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.