ArticleCancers2021
Familial Risks and Proportions Describing Population Landscape of Familial Cancer.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pooled it
- Clinical implementation of polygenic risk scores.European journal of human genetics : EJHG · 2026Article
- Familial risks in prostate cancer between brothers and half-brothers as clues to germline genetic and environmental causes.Familial cancer · 2026Article
- Familial Risks in 317 000 Patients With Prostate Cancer in Relation to Metastases and Survival-Guiding Diagnostics.European urology open science · 2026Article
- Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective "ProFam-Risk" Study.European urology open science · 2026Article
- Exploring current cancer screening practices and guidelines for adults under age 50 in the United States.Frontiers in public health · 2026Article
- Familial colorectal cancer: search for novel predisposition genes.Human genomics · 2025Article
- Pathogenic variants in affected and unaffected individuals from Indonesian familial cancer: a multigene panel analysis.Scientific reports · 2025Article
- Second Primary Lung Cancer Associated With Family History of Lung Cancer.Cancer medicine · 2025Article
- Risk of mortality in family members of men seeking fertility assessment.Fertility and sterility · 2025Article
- Germline homologous recombination repair (gHRR) variants in bladder cancer: Preliminary evidence and clinical implications.BJUI compass · 2025Article
- Sex specific familial risk in lung cancer through changing histologies in Sweden.International journal of cancer · 2025Article
- Symptom and functional networks of patients with cancer in different latent risk subgroups based on patient-reported outcomes.BMC cancer · 2025Article
- Getting Cancer Is "Just Bad Luck": Exploring Bereaved Emerging and Young Adults' Cancer Risk Uncertainty After Caring for a Parent With Advanced Cancer.Psycho-oncology · 2025Article
- Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers.International journal of cancer · 2025Article
- Genomic analysis revealing Lynch syndrome in a case of high-grade glioma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- High familial risks in some rare cancers may pinpoint to hidden germline genetics: focus on esophageal, stomach, small intestinal, testis, thyroid and bone cancers.Hereditary cancer in clinical practice · 2025Review
- Age-specific familial risks in cancer as clues to germline genetic and environmental causes: focus on colorectal, endometrial, prostate, kidney, breast and lung cancers.Hereditary cancer in clinical practice · 2025Review
- Esophageal Cancer in a Patient With Poland Syndrome.Ochsner journal · 2025Article
- Hereditary and Familial Traits in Urological Cancers and Their Underlying Genes.European urology open science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family database in the world with complete family structures and medically confirmed cancers. PATIENTS/
methodsWe employed standardized incidence ratios (SIRs) to estimate familial risks for concordant cancer among first-degree relatives using the Swedish Cancer Registry from years 1958 through 2016.
resultsCancer risks in a 20-84 year old population conferred by affected parents or siblings were about two-fold compared to the risk for individuals with unaffected relatives. For small intestinal, testicular, thyroid and bone cancers and Hodgkin disease, risks were higher, five-to-eight-fold. Novel familial associations included adult bone, lip, pharyngeal, and connective tissue cancers. Familial cancers were found in 13.2% of families with cancer; for prostate cancer, the proportion was 26.4%. High-risk families accounted for 6.6% of all cancer families. DISCUSSION/
conclusionHigh-risk family history should be exceedingly considered for management, including targeted genetic testing. For the major proportion of familial clustering, where genetic testing may not be feasible, medical and behavioral intervention should be indicated for the patient and their family members, including screening recommendations and avoidance of carcinogenic exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.