Evidence map›Paper›PMID 34503183›Full record

ReviewCancers2021

Free Periosteal Flaps with Scaffold: An Overlooked Armamentarium for Maxillary and Mandibular Reconstruction.

Remo Accorona, Luca Gazzini, Roberto Grigolato, Enrico Fazio, Letizia Nitro, Monir Abousiam, Giovanni Giorgetti, Lorenzo Pignataro, Pasquale Capaccio, Luca Calabrese

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Pedicle Ossification-induced Thrombosis and Sequential Fibula Free Flap Failures.Plastic and reconstructive surgery. Global open · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Remo AccoronaDepartment of Otorhinolaryngology-Head and Neck Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Luca GazziniDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.
Roberto GrigolatoDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.ORCID 0000-0002-8634-6592
Enrico FazioDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.
Letizia NitroDepartment of Otorhinolaryngology-Head and Neck Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Monir AbousiamDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.
Giovanni GiorgettiDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.
Lorenzo PignataroDepartment of Otorhinolaryngology-Head and Neck Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Pasquale CapaccioDepartment of Otorhinolaryngology-Head and Neck Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Luca CalabreseDivision of Otorhinolaryngology, "San Maurizio" Hospital, 39100 Bolzano, Italy.
Ospedale di Bolzano · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHead and neck bone reconstruction is a challenging surgical scenario. Although several strategies have been described in the literature, bone free flaps (BFFs) have become the preferred technique for large defects. Revascularized free periosteal flaps (FPFs) with support scaffold represents a possible alternative in compromised patient, BFF failure, or relapsing cancers as salvage treatment. However, only few clinical applications in head and neck are reported in literature. Purpose of the study was to systematically analyse the results of functional and oncologic maxillary and mandibular reconstruction with FPF with scaffold. MATERIALS AND

methodsA comprehensive review of the dedicated literature was performed according to the PRISMA guidelines searching on Scopus, PubMed/MEDLINE, Cochrane Library, Embase, Researchgate and Google Scholar databases using relevant keywords, phrases and medical subject headings (MeSH) terms. An excursus on the most valuable FPF' harvesting sites was also carried out.

resultsA total of 7 studies with 55 patients were included. Overall, the majority of the patients (

conclusionsMaxillary and mandibular reconstruction with FPF and scaffold is a possible alternative in patient unfit for complex BFF reconstruction and it should be considered as a valid alternative in the sequential salvage surgery for locally advanced cancer. Moreover, it opens future scenarios in head and neck reconstructive surgery, as a promising tool that can be modelled to tailor complex 3D defects, with less morbidities to the donor site.

Indexed as

free flapfree periosteal flaphead and neck reconstructionperiosteum

Identifiers

PMID34503183
PMCPMC8431391
OpenAlexW3196514757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.