Evidence map›Paper›PMID 34503117›Full record

ArticleCancers2021

IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma.

Diana Maržić, Blažen Marijić, Tamara Braut, Stefan Janik, Manuela Avirović, Ita Hadžisejdić, Filip Tudor, Katarina Radobuljac, Miran Čoklo, Boban M Erovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. [Research progress on the role and mechanism of IGF2BPs family in head and neck squamous carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  3. Article
  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Diana MaržićDepartment of Audiology and Phoniatrics, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia.
Blažen MarijićFaculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0001-6094-7114
Tamara BrautFaculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Stefan JanikDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, 1190 Vienna, Austria.ORCID 0000-0002-1161-4871
Manuela AvirovićFaculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Ita HadžisejdićFaculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0003-1800-3552
Filip TudorFaculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0001-6386-0444
Katarina RadobuljacDepartment of Audiology and Phoniatrics, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia.
Miran ČokloCenter for Applied Bioanthropology, Institute for Anthropological Research, 10000 Zagreb, Croatia.
Boban M ErovicInstitute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria.ORCID 0000-0001-5706-1056
University of Rijeka · HRInstitute for Anthropological Research · HRMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC).

methodsIMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules).

resultsIMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (

conclusionSince IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx.

Indexed as

dysplasiaimmunohistochemistryIMP3laryngeal carcinomasurvival

Identifiers

PMID34503117
PMCPMC8430545
OpenAlexW3193597204

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.