ArticlePolymers2021
In Vitro Assessment of the Cell Metabolic Activity, Cytotoxicity, Cell Attachment, and Inflammatory Reaction of Human Oral Fibroblasts on Polyetheretherketone (PEEK) Implant-Abutment.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review.Journal of functional biomaterials · 2026Review
- Review
- The impact of hyaluronic acid coating on polyether ether ketone dental implant surface: An in vitro analysis.The Saudi dental journal · 2024Article
- Characterization and biocompatibility of a bilayer PEEK-based scaffold for guiding bone regeneration.BMC oral health · 2024Article
- The Biocompatibility and the Effect of Titanium and PEKK on the Osseointegration of Customized Facial Implants.Materials (Basel, Switzerland) · 2024Article
- Article
- Enhancing Dental Cement Bond Strength with Autofocus-Laser-Cutter-Generated Grooves on Polyetheretherketone Surfaces.Polymers · 2023Article
- The integration of peri-implant soft tissues around zirconia abutments: Challenges and strategies.Bioactive materials · 2023Review
- Precision of polyether ether ketone (PEEK) or cobalt-chrome implant bar fit to implants after mechanical cycling.Acta odontologica latinoamericana : AOL · 2023Article
- State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants.Frontiers in bioengineering and biotechnology · 2023Review
- Cell Type-Specific Effects of Implant Provisional Restoration Materials on the Growth and Function of Human Fibroblasts and Osteoblasts.Biomimetics (Basel, Switzerland) · 2022Article
- Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry.Polymers · 2022Review
- Biomaterials and Clinical Applications of Customized Healing Abutment-A Narrative Review.Journal of functional biomaterials · 2022Review
- Influence of the Peek Abutments on Mechanical Behavior of the Internal Connections Single Implant.Materials (Basel, Switzerland) · 2022Article
- Effects of Temoporfin-Based Photodynamic Therapy on the In Vitro Antibacterial Activity and Biocompatibility of Gelatin-Hyaluronic Acid Cross-Linked Hydrogel Membranes.Pharmaceutics · 2022Article
- Two Gingival Cell Lines Response to Different Dental Implant Abutment Materials: An In Vitro Study.Dentistry journal · 2022Article
- Article
- Review
- Prosthetic Materials Used for Implant-Supported Restorations and Their Biochemical Oral Interactions: A Narrative Review.Materials (Basel, Switzerland) · 2022Review
- Assessing the role of PEKK implant material on cytotoxicity, inflammatory response, and molecular interactions with pro-inflammatory cytokines: An in-vitro and in-silico study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
The purpose of this research is to compare the cytotoxicity of polyetheretherketone (PEEK) and polyetherketoneketone (PEKK) with conventional dental implant-abutment materials, namely titanium alloy (Ti-6Al-4V) and yttria-stabilized tetragonal zirconia polycrystal (Y-TZP), to evaluate the cell metabolic activity, cytotoxicity, and inflammation potential of human oral fibroblasts (HOF) on these materials. Disk-shaped specimens were designed and prepared via a dental computer-aided manufacturing technology system. Surface topography, roughness, and free energy were investigated by atomic force microscope and contact angle analyzer; cell metabolic activity and cytotoxicity by MTT assay; and morphological changes by scanning electron microscopy (SEM). The effect of pro-inflammatory gene expression was evaluated by RT-qPCR. The obtained data were analyzed with one-way analysis of variance and post-hoc Tukey's honest significant difference tests. PEEK and PEKK exhibited higher submicron surface roughness (0.04 μm) and hydrophobicity (>80°) than the control. Although the cell activity of PEEK was lower than that of Ti-6Al-4V and Y-TZP for the first 24 h (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.