ArticlePolymers2021
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Development of injectable cuttlebone derived nanohydroxyapatite hydrogel for osteoblast cell encapsulation.Biochemistry and biophysics reports · 2025Article
- Incorporation of Natural Biostimulants in Biodegradable Mulch Films for Agricultural Applications: Ecotoxicological Evaluation.Polymers · 2025Article
- Laboratory performance of novel injectable keratin nanoparticle from poultry feathers loaded-alginate composite hydrogel as a pulpotomy filling biomaterial for dentin regeneration.BMC oral health · 2025Article
- Article
- Chemically Crosslinked Alginate Hydrogel with Polyaziridine: Effects on Physicochemical Properties and Promising Applications.ChemPlusChem · 2025Article
- Zinc Acetate as a Cross-Linking Agent in the Development of Enteric Microcapsules for Posaconazole.Pharmaceutics · 2025Article
- Effective adsorptive removal of triclosan from water using bio-nanocomposite hydrogel beads.Frontiers in chemistry · 2025Article
- A novel injectable boron doped-mesoporous nano bioactive glass loaded-alginate composite hydrogel as a pulpotomy filling biomaterial for dentin regeneration.BMC oral health · 2024Article
- Feasibility of Invasive Brown SeaweedPolymers · 2024Article
- Slow-sculpting graphene oxide/alginate gel loaded with platelet-rich plasma to promote wound healing in rats.Frontiers in bioengineering and biotechnology · 2024Article
- Alginate-based composites as novel soil conditioners for sustainable applications in agriculture: A critical review.Journal of environmental management · 2023Review
- Mucoadhesive Alginate/Pectin Films Crosslinked by Calcium Carbonate as Carriers of a Model Antifungal Drug-Posaconazole.Pharmaceutics · 2023Article
- Fucoidan-Incorporated Composite Scaffold Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells for Bone Tissue Engineering.Marine drugs · 2022Article
- Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In recent years, researchers working in biomedical science and technology have investigated alternatives for enhancing the mechanical properties of biomedical materials. In this work, sodium alginate (SA) hydrogel-reinforced nanoparticles (NPs) of hydroxyapatite (HA) were prepared to enhance the mechanical properties of this polymer. Compression tests showed an increase of 354.54% in ultimate compressive strength (UCS), and 154.36% in Young's modulus with the addition of these NPs compared with pure SA. Thermogravimetric analysis (TGA) revealed that the amount of residual water is not negligible and covered a range from 20 to 35 wt%, and the decomposition degree of the alginate depends on the hydroxyapatite content, possibly due to the displacement of sodium ions by the hydroxyapatite and not by calcium chloride. Further, there is an important effect possibly due to the existence of an interaction of hydrogen bonds between the hydroxyl of the alginate and the oxygen atoms of the hydroxyapatite, so signals appear upfield in nuclear magnetic resonance (NMR) data. An increase in the accumulation of HA particles was observed with the use of X-ray microtomography, in which the quantified volume of particles per reconstructed volume corresponded accordingly to the increase in the mechanical properties of the hydrogel.
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