Evidence map›Paper›PMID 34502937›Full record

ArticlePolymers2021

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems.

Carmelo Corsaro, Giulia Neri, Angela Maria Mezzasalma, Enza Fazio

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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  8. TXRF Spectrometry for Investigating CaFInternational journal of molecular sciences · 2026
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  14. A self-wrapping, bioresorbable neural interface for wireless multimodal therapy of localized peripheral nerve injury.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carmelo CorsaroDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-1497-8750
Giulia NeriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-4458-0022
Angela Maria MezzasalmaDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Enza FazioDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0001-9132-7073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More attention has recently been paid to synthetic polyelectrolytes for their intrinsic properties which allow them to rearrange into compact structures, ideal to be used as drug carriers or probes influencing biochemical processes. The presence of Ag nanoparticles (NPs) in the Poly methyl acrylate (PMA) matrix leads to an enhancement of drug release efficiency, even using a low-power laser whose wavelength is far from the Ag Surface Plasmon Resonance (SPR) peak. Further, compared to the colloids, the nanofiber-based drug delivery system has shown shorter response time and more precise control over the release rate. The efficiency and timing of involved drug release mechanisms has been estimated by the Weibull distribution function, whose parameters indicate that the release mechanism of nanofibers obeys Fick's first law while a non-Fickian character controlled by diffusion and relaxation of polymer chains occurs in the colloidal phase.

Indexed as

Ag nanoparticlesdrug nanocarrierphotoreduction processPoly(methacrylic acid) sodium saltsmart nanodevicestatistical distributionsWeibull function

Identifiers

PMID34502937
PMCPMC8434431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.