Evidence map›Paper›PMID 34502880›Full record

ArticlePolymers2021

Succinylation of Polyallylamine: Influence on Biological Efficacy and the Formation of Electrospun Fibers.

Lucija Jurko, Matej Bračič, Silvo Hribernik, Damjan Makuc, Janez Plavec, Filip Jerenec, Sonja Žabkar, Nenad Gubeljak, Alja Štern, Rupert Kargl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lucija JurkoLaboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
Matej BračičLaboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.ORCID 0000-0003-0213-6772
Silvo HribernikLaboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
Damjan MakucSlovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Janez PlavecSlovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.ORCID 0000-0003-1570-8602
Filip JerenecFaculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
Sonja ŽabkarDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 11, 1000 Ljubljana, Slovenia.
Nenad GubeljakFaculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
Alja ŠternDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 11, 1000 Ljubljana, Slovenia.ORCID 0000-0001-7531-1215
Rupert KarglLaboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
University of Maribor · SINational Institute of Biology · SIEN-FIST Centre of Excellence (Slovenia) · SIUniversity of Ljubljana · SI

Funding

H2020 Marie Skłodowska-Curie Actions 764713
6 · The paper itself

Abstract

Succinylation of proteins is a commonly encountered reaction in biology and introduces negatively charged carboxylates on previously basic primary amine groups of amino acid residues. In analogy, this work investigates the succinylation of primary amines of the synthetic polyelectrolyte polyallylamine (PAA). It investigates the influence of the degree of succinylation on the cytotoxicity and antibacterial activity of the resulting polymers. Succinylation was performed in water with varying amounts of succinic anhydride and at different pH values. The PAA derivatives were analyzed in detail with respect to molecular structure using nuclear magnetic resonance and infrared absorbance spectroscopy. Polyelectrolyte and potentiometric charge titrations were used to elucidate charge ratios between primary amines and carboxylates in the polymers. The obtained materials were then evaluated with respect to their minimum inhibitory concentration against

Indexed as

antimicrobial effectaqueous chemistrycytotoxicityelectrospinningnanofibers: mouse L929 fibroblastspolyallylamine hydrochloridePseudomonas aeruginosaStaphylococcus aureussuccinylation

Identifiers

PMID34502880
PMCPMC8433649
OpenAlexW3193355328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.