Evidence map›Paper›PMID 34502603›Full record

ArticleSensors (Basel, Switzerland)2021

A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck

Mauro Maniscalco, Pasquale Ambrosino, Anna Ciullo, Salvatore Fuschillo, Valerio Valente, Carlo Gaudiosi, Debora Paris, Raffaele Cobuccio, Francesco Stefanelli, Andrea Motta

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mauro ManiscalcoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0001-6751-9921
Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0002-9398-0428
Anna CiulloIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Salvatore FuschilloIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Valerio ValenteIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Carlo GaudiosiDepartment of Respiratory Medicine, Boscotrecase Covid Hospital, 80042 Boscotrecase, Italy.
Debora ParisInstitute of Biomolecular Chemistry, National Research Council, ICB-CNR, 80078 Pozzuoli, Italy.
Raffaele CobuccioDepartment of Respiratory Medicine, Boscotrecase Covid Hospital, 80042 Boscotrecase, Italy.
Francesco StefanelliDepartment of Respiratory Medicine, Boscotrecase Covid Hospital, 80042 Boscotrecase, Italy.
Andrea MottaInstitute of Biomolecular Chemistry, National Research Council, ICB-CNR, 80078 Pozzuoli, Italy.ORCID 0000-0002-8643-658X
Istituti Clinici Scientifici Maugeri · ITIstituto di Chimica Biomolecolare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck

methodsWe performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck

resultsA total of 105 individuals (41 females, 39.0%; 64 males, 61.0%; mean age: 58.4 years) were included in the final analysis, with the RT-PCR being positive in 13 (12.4%) and negative in 92 (87.6%). The agreement between the two methods was 98.1%, with a Cohen's κ score of 0.91 (95% CI: 0.79-1.00). The overall sensitivity and specificity of the Inflammacheck

conclusionsThe modified Inflammacheck

Indexed as

COVID-19SARS-CoV-2Cross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsSensitivity and SpecificityCOVID-19disabilityexerciseoutcomerehabilitationSARS-CoV-2

Identifiers

PMID34502603
PMCPMC8434102
OpenAlexW3193326705

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.