Evidence map›Paper›PMID 34502510›Full record

ArticleInternational journal of molecular sciences2021

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants.

Alessandra Colombini, Paola De Luca, Davide Cangelosi, Carlotta Perucca Orfei, Enrico Ragni, Marco Viganò, Michela Malacarne, Mauro Castagnetta, Marco Brayda-Bruno, Domenico Coviello and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alessandra ColombiniOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-1800-3424
Paola De LucaOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-9810-8818
Davide CangelosiLaboratorio di Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Carlotta Perucca OrfeiOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-6162-8668
Enrico RagniOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0003-0272-7417
Marco ViganòOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-6463-6564
Michela MalacarneLaboratorio di Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Mauro CastagnettaLaboratorio di Istocompatibilità/IBMDR, Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0002-8052-9515
Marco Brayda-BrunoScoliosis Unit, Department of Orthopedics and Traumatology-Spine Surgery III, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Domenico CovielloLaboratorio di Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-8440-865X
Laura de GirolamoOrthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-9979-3092
Istituto Ortopedico Galeazzi · ITIstituto Giannina Gaslini · ITEnte Ospedaliero Ospedali Galliera · IT

Funding

Italian Ministry of Health Ricerca Corrente
6 · The paper itself

Abstract

Vitamin D showed a protective effect on intervertebral disc degeneration (IDD) although conflicting evidence is reported. An explanation could be due to the presence of the FokI functional variant in the vitamin D receptor (

Indexed as

AdultFemaleGenotypeHigh-Throughput Nucleotide SequencingHumansIntervertebral DiscIntervertebral Disc DegenerationMiddle AgedPolymorphism, Single NucleotideProteomicsReceptors, CalcitriolVitamin DVitaminsReceptors, CalcitriolVDR protein, humanVitamin DVitaminsgene profileinflammationintervertebral discprotein profilevitamin Dvitamin D receptor gene polymorphism

Identifiers

PMID34502510
PMCPMC8431769
OpenAlexW3196345671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.