Evidence map›Paper›PMID 34502497›Full record

ArticleInternational journal of molecular sciences2021

Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer.

Nam Hee Kim, Sang Hyun Song, Yun Hee Choi, Kyu Ho Hwang, Jun Seop Yun, Hyeeun Song, So Young Cha, Sue Bean Cho, Inhan Lee, Hyun Sil Kim and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Nam Hee KimDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID 0000-0002-3087-5276
Sang Hyun SongDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Yun Hee ChoiDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Kyu Ho HwangDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Jun Seop YunDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Hyeeun SongDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
So Young ChaDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Sue Bean ChoDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Inhan LeeResearch Division, miRCore, Ann Arbor, MI 48105, USA.
Hyun Sil KimDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID 0000-0003-3614-1764
Jong In YookDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID 0000-0002-7318-6112
Yonsei University · KR

Funding

National Research Foundation of Korea NRF-2017R1A2B3002241National Research Foundation of Korea NRF-2018M3A9E2022820National Research Foundation of Korea NRF-2019R1A2C2084535National Research Foundation of Korea NRF-2021R1A2C3003496
6 · The paper itself

Abstract

The epithelial-mesenchymal transition (EMT) comprises an important biological mechanism not only for cancer progression but also in the therapeutic resistance of cancer cells. While the importance of the protein abundance of EMT-inducers, such as Snail (SNAI1) and Zeb1 (ZEB1), during EMT progression is clear, the reciprocal interactions between the untranslated regions (UTRs) of EMT-inducers via a competing endogenous RNA (ceRNA) network have received little attention. In this study, we found a synchronized transcript abundance of Snail and Zeb1 mediated by a non-coding RNA network in colorectal cancer (CRC). Importantly, the

Indexed as

Genes, Tumor SuppressorAnimalsColorectal NeoplasmsFemaleHCT116 CellsHumansMiceMice, NudeMicroRNAsNeoplasm ProteinsRNA, NeoplasmSnail Family Transcription FactorsZinc Finger E-box-Binding Homeobox 1MicroRNAsMIRN200 microRNA, humanMIRN34 microRNA, humanNeoplasm ProteinsRNA, NeoplasmSNAI1 protein, humanSnail Family Transcription FactorsZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1ceRNAcolorectal cancerepithelial mesenchymal transitionSnailtherapeutic resistanceZEB1

Identifiers

PMID34502497
PMCPMC8431469
OpenAlexW3197976427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.