Evidence map›Paper›PMID 34502494›Full record

ArticleInternational journal of molecular sciences2021

Impact of Reactive Oxygen and Nitrogen Species Produced by Plasma on Mdm2-p53 Complex.

Pankaj Attri, Hirofumi Kurita, Kazunori Koga, Masaharu Shiratani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pankaj AttriCenter of Plasma Nano-Interface Engineering, Kyushu University, Fukuoka 819-0395, Japan.ORCID 0000-0002-5036-7877
Hirofumi KuritaDepartment of Applied Chemistry and Life Science, Toyohashi University of Technology, Toyohashi 441-8580, Aichi, Japan.ORCID 0000-0002-2538-6590
Kazunori KogaFaculty of Information Science and Electrical Engineering, Kyushu University, Fukuoka 819-0395, Japan.ORCID 0000-0002-9214-7493
Masaharu ShirataniCenter of Plasma Nano-Interface Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Kyushu University · JPToyohashi University of Technology · JP

Funding

Japan Society for the Promotion of Science 20K14454
6 · The paper itself

Abstract

The study of protein-protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)-tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2-p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.

Indexed as

HumansMultiprotein ComplexesPlasma GasesProto-Oncogene Proteins c-mdm2Reactive Nitrogen SpeciesReactive Oxygen SpeciesTumor Suppressor Protein p53MDM2 protein, humanMultiprotein ComplexesPlasma GasesProto-Oncogene Proteins c-mdm2Reactive Nitrogen SpeciesReactive Oxygen SpeciesTP53 protein, humanTumor Suppressor Protein p53Mdm2–p53molecular dynamic (MD) simulationsplasma treatment

Identifiers

PMID34502494
PMCPMC8431430
OpenAlexW3197617346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.