Evidence map›Paper›PMID 34502484›Full record

ArticleInternational journal of molecular sciences2021

Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes.

Thatchawan Thanasupawat, Aleksandra Glogowska, Christopher Pascoe, Sai Nivedita Krishnan, Maliha Munir, Farhana Begum, Jason Beiko, Jerry Krcek, Marc R Del Bigio, Marshall Pitz and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Measuring biological age using omics data.Nature reviews. Genetics · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thatchawan ThanasupawatDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Aleksandra GlogowskaDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Christopher PascoeDepartment of Physiology & Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0002-5229-9927
Sai Nivedita KrishnanDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Maliha MunirDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Farhana BegumDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Jason BeikoDepartment of Surgery, University of Manitoba, Winnipeg, MB R3E 0Z2, Canada.
Jerry KrcekDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0003-3347-8935
Marc R Del BigioDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0001-8366-0394
Marshall PitzDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Yaoqing ShenCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Victor SpicerManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB R3E 3P4, Canada.
Kevin M CoombsChildren's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.ORCID 0000-0001-7667-8430
John WilkinsDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 0Z2, Canada.
Sabine Hombach-KlonischDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0001-8071-2486
Thomas KlonischDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0003-0448-6741

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant gliomas derive from brain glial cells and represent >75% of primary brain tumors. This includes anaplastic astrocytoma (grade III; AS), the most common and fatal glioblastoma multiforme (grade IV; GBM), and oligodendroglioma (ODG). We have generated patient-derived AS, GBM, and ODG cell models to study disease mechanisms and test patient-centered therapeutic strategies. We have used an aptamer-based high-throughput SOMAscan

Indexed as

ProteomicsAptamers, NucleotideBrain NeoplasmsGliomaHumansNeoplasm ProteinsProteomeTumor Cells, CulturedAptamers, NucleotideNeoplasm ProteinsProteomeglioblastomagliomapatient cell isolatesproteomic clustersSOMAmers

Identifiers

PMID34502484
PMCPMC8431317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.