Evidence map›Paper›PMID 34502464›Full record

ArticleInternational journal of molecular sciences2021

Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry.

Fabiana Henriques Machado de Melo, Diego Assis Gonçalves, Ricardo Xisto de Sousa, Marcelo Yudi Icimoto, Denise de Castro Fernandes, Francisco R M Laurindo, Miriam Galvonas Jasiulionis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Fabiana Henriques Machado de MeloPharmacology Department, Universidade Federal de São Paulo, São Paulo 05508-090, Brazil.
Diego Assis GonçalvesMicro-Imuno-Parasitology Department, Universidade Federal de São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-7351-3558
Ricardo Xisto de SousaDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo 01221-020, Brazil.
Marcelo Yudi IcimotoBiophysics Department, Universidade Federal de São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-0746-5279
Denise de Castro FernandesVascular Biology Laboratory, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo 05508-060, Brazil.
Francisco R M LaurindoVascular Biology Laboratory, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo 05508-060, Brazil.
Miriam Galvonas JasiulionisPharmacology Department, Universidade Federal de São Paulo, São Paulo 05508-090, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversidade Federal de Juiz de Fora · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/13663-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/04352-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/10695-7
6 · The paper itself

Abstract

Melanoma is the most aggressive type of skin cancer due to its high capability of developing metastasis and acquiring chemoresistance. Altered redox homeostasis induced by increased reactive oxygen species is associated with melanomagenesis through modulation of redox signaling pathways. Dysfunctional endothelial nitric oxide synthase (eNOS) produces superoxide anion (O

Indexed as

Down-RegulationGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticAnimalsBiopterinsFemaleHumansMelanomaMiceNeoplasm MetastasisNeoplasm ProteinsNitric Oxide Synthase Type IIIBiopterinsNeoplasm ProteinsNitric Oxide Synthase Type IIINOS3 protein, humaneNOS:BH4 stoichiometryeNOS uncouplingL-sepiapterinmetastatic melanomatetrahydrobiopterin

Identifiers

PMID34502464
PMCPMC8430733
OpenAlexW3197282651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.