ArticleInternational journal of molecular sciences2021
Fibrin Network Formation and Lysis in Septic Shock Patients.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Real-Time Fibrinolysis Monitoring of Plasma Annular Clots.Biomolecules · 2026Article
- The Fibrinolytic System in Bacterial Sepsis: A Comprehensive Review of Current Assessment Methods.Journal of clinical medicine · 2025Review
- Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study.Current medical science · 2025Article
- Fibrinogen Oxidation and Thrombosis: Shaping Structure and Function.Antioxidants (Basel, Switzerland) · 2025Review
- Construction and efficacy evaluation of a model for early diagnosis of pediatric sepsis based on LASSO-logistic regression.Frontiers in pediatrics · 2025Article
- Impaired Whole-Blood Fibrinolysis is a Predictor of Mortality in Intensive Care Patients.TH open : companion journal to thrombosis and haemostasis · 2024Article
- The Fibrinolytic System and Its Measurement: History, Current Uses and Future Directions for Diagnosis and Treatment.International journal of molecular sciences · 2023Review
- Fibrin clot properties in cardiovascular disease: from basic mechanisms to clinical practice.Cardiovascular research · 2023Review
- Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation.Research and practice in thrombosis and haemostasis · 2023Article
- Modified Rotational Thromboelastometry Protocol Using Tissue Plasminogen Activator for Detection of Hypofibrinolysis and Hyperfibrinolysis.Methods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSeptic shock patients are prone to altered fibrinolysis, which contributes to microthrombus formation, organ failure and mortality. However, characterisation of the individual patient's fibrinolytic capacity remains a challenge due to a lack of global fibrinolysis biomarkers. We aimed to assess fibrinolysis in septic shock patients using a plasma-based fibrin clot formation and lysis (clot-lysis) assay and investigate the association between clot-lysis parameters and other haemostatic markers, organ dysfunction and mortality.
methodsThis was a prospective cohort study including adult septic shock patients (
resultsThree distinct clot-lysis profiles emerged in the patients: (1) severely decreased fibrin formation (flat clot-lysis curve), (2) normal fibrin formation and lysis and (3) pronounced lysis resistance. Patients with abnormal curves had lower platelet counts (
conclusionSeptic shock patients showed distinct and abnormal clot-lysis profiles that were associated with markers of coagulation and organ dysfunction. Our results provide important new insights into sepsis-related fibrinolysis disturbances and support the importance of assessing fibrinolytic capacity in septic shock.
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