Evidence map›Paper›PMID 34502412›Full record

ReviewInternational journal of molecular sciences2021

Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders.

Juan Prieto-Villalobos, Tanhia F Alvear, Andrés Liberona, Claudia M Lucero, Claudio J Martínez-Araya, Javiera Balmazabal, Carla A Inostroza, Gigliola Ramírez, Gonzalo I Gómez, Juan A Orellana

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Role of astrocytes connexins - pannexins in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. Article
  4. Calcium Regulation of Connexin Hemichannels.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Connexins Control Glial Inflammation in Various Neurological Diseases.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Juan Prieto-VillalobosDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Tanhia F AlvearDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Andrés LiberonaDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.ORCID 0000-0003-4091-8038
Claudia M LuceroInstitute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile.
Claudio J Martínez-ArayaDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Javiera BalmazabalDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Carla A InostrozaDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Gigliola RamírezDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Gonzalo I GómezInstitute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile.ORCID 0000-0001-7761-8675
Juan A OrellanaDepartamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.ORCID 0000-0003-4076-207X
Pontificia Universidad Católica de Chile · CLUniversidad Autónoma de Chile · CL

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 1210375
6 · The paper itself

Abstract

Maternal inflammation during pregnancy causes later-in-life alterations of the offspring's brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia, intellectual disability, bipolar disorder, autism spectrum disorder, microcephaly, and cerebral palsy. Here, we discuss how astrocytes might contribute to postnatal brain dysfunction following maternal inflammation, focusing on the signaling mediated by two families of plasma membrane channels: hemi-channels and pannexons. [Ca

Indexed as

Mental DisordersPregnancy ComplicationsPrenatal Exposure Delayed EffectsAstrocytesBiological Transport, ActiveFemaleHumansInflammationIon ChannelsNeurodevelopmental DisordersPregnancyIon Channelsastrocyteconnexinsexcitotoxicityhemichannelslipopolysaccharidemicroglianeurodegenerationneuroinflammationneuronpannexinspannexons

Identifiers

PMID34502412
PMCPMC8430734
OpenAlexW3196688382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.