Evidence map›Paper›PMID 34502409›Full record

ArticleInternational journal of molecular sciences2021

Impaired Differentiation of Highly Proliferative ICOS

Florian Kälble, Lisa Wu, Hanns-Martin Lorenz, Martin Zeier, Matthias Schaier, Andrea Steinborn

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Exhaustion of CD8Frontiers in immunology · 2025
    Article
  5. Review
  6. Sex-specific differences in ICOSClinical and experimental medicine · 2024
    Article
  7. Exhaustion of CD8Frontiers in immunology · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Florian KälbleDepartment of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.
Lisa WuDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Hanns-Martin LorenzDepartment of Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany.
Martin ZeierDepartment of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.
Matthias SchaierDepartment of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1040-1150
Andrea SteinbornDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulations in the differentiation of CD4

Indexed as

AdultCell DifferentiationCells, CulturedFemaleHumansImmunologic MemoryInducible T-Cell Co-Stimulator ProteinLupus Erythematosus, SystemicLymphocyte ActivationMaleMiddle AgedT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsICOS protein, humanInducible T-Cell Co-Stimulator Proteinactive diseaseinducible costimulatory molecule (ICOS)recent thymic emigrants (RTEs)regulatory T-cells (Tregs)resting mature naïve cells (MNs)systemic lupus erythematosus (SLE)Treg/Tresp cell differentiation

Identifiers

PMID34502409
PMCPMC8430608
OpenAlexW3196961441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.