Evidence map›Paper›PMID 34502392›Full record

ArticleInternational journal of molecular sciences2021

Jan Kotál, Stéphanie G I Polderdijk, Helena Langhansová, Monika Ederová, Larissa A Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A Huntington and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Serpins in the Spotlight: Novel Bioinformatic Insights IntoBiochemistry research international · 2025
    Article
  7. Review
  8. Egg Protein Compositions over Embryonic Development inAnimals : an open access journal from MDPI · 2024
    Article
  9. Article
  10. Conformational transition of the Ixodes ricinus salivary serpin Iripin-4.Acta crystallographica. Section D, Structural biology · 2023
    Article
  11. Editorial: Special Issue on the "Molecular Biology of Disease Vectors".International journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Frontiers in veterinary science · 2022
    Article
  15. Serpins in Tick Physiology and Tick-Host Interaction.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Immunomodulatory Proteins in Tick Saliva From a Structural Perspective.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jan KotálDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.ORCID 0000-0002-5644-1468
Stéphanie G I PolderdijkCambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.ORCID 0000-0002-4210-6677
Helena LanghansováDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.
Monika EderováDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.
Larissa A MartinsLaboratory of Genomics and Proteomics of Disease Vectors, Institute of Parasitology, Biology Center CAS, Branišovská 1160/31, 37005 České Budějovice, Czech Republic.ORCID 0000-0001-8127-6276
Zuzana BeránkováDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.
Adéla ChlastákováDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.ORCID 0000-0003-0277-140X
Ondřej HajdušekLaboratory of Vector Immunology, Institute of Parasitology, Biology Center CAS, Branišovská 1160/31, 37005 České Budějovice, Czech Republic.
Michail KotsyfakisDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.ORCID 0000-0002-7526-1876
James A HuntingtonCambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Jindřich ChmelařDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760c, 37005 České Budějovice, Czech Republic.ORCID 0000-0002-7089-6143
University of South Bohemia in České Budějovice · CZInstitute of Parasitology · CZUniversity of Cambridge · GB

Funding

European Regional Development Fund 384 CZ.02.1.01/0.0/0.0/16_019/0000759Grantová Agentura České Republiky 19-14704Y
6 · The paper itself

Abstract

Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne pathogens. Here we present the functional and structural characterization of Iripin-8, a salivary serpin from the tick

Indexed as

AnimalsArthropod ProteinsBlood CoagulationComplement ActivationComplement System ProteinsErythrocytesGene ExpressionGene Expression RegulationIxodesLyme DiseaseNymphSalivaSalivary GlandsSerpinsArthropod ProteinsComplement System ProteinsSerpinsblood coagulationcrystal structureIxodes ricinusparasitesalivaserpintick

Identifiers

PMID34502392
PMCPMC8431025
OpenAlexW3197007482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.