Evidence map›Paper›PMID 34502350›Full record

ReviewInternational journal of molecular sciences2021

Recent Advancements in the Medical Treatment of Diabetic Retinal Disease.

Maja Szymanska, Daanyaal Mahmood, Timothy E Yap, Maria F Cordeiro

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. AI-based fluid quantification in neovascular age-related macular degeneration and diabetic macular edema treated with faricimab - a real-life study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maja SzymanskaThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
Daanyaal MahmoodThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
Timothy E YapThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
Maria F CordeiroThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, intravitreal therapy commonly requires frequent hospital visits and some patients fail to achieve a significant improvement in vision. Novel and long-acting therapies targeting a range of pathways are warranted, while evidence to support optimal combinations of treatments is currently insufficient. Improved understanding of the molecular pathways involved in pathogenesis is driving the development of therapeutic agents not only targeting visible microvascular disease and metabolic derangements, but also inflammation and accelerated retinal neurodegeneration. This review summarizes the current and emerging treatments of diabetic retinal diseases and provides an insight into the future of managing this important condition.

Indexed as

Angiogenesis InhibitorsDiabetes ComplicationsDiabetes MellitusDiabetic RetinopathyGlucocorticoidsGlycemic ControlHumansInflammationIntravitreal InjectionsMacular EdemaRetinaVascular Endothelial Growth Factor AAngiogenesis InhibitorsGlucocorticoidsVascular Endothelial Growth Factor Aangiogenesisanti-VEGFcorticosteroidsdiabetic macular edemadiabetic retinopathyglycemic controlinflammationislet cell transplantationpancreatic transplantation

Identifiers

PMID34502350
PMCPMC8430918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.