Evidence map›Paper›PMID 34502319›Full record

ArticleInternational journal of molecular sciences2021

A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML.

Jacob Jalil Hassan, Anna Lieske, Nicole Dörpmund, Denise Klatt, Dirk Hoffmann, Marc-Jens Kleppa, Olga S Kustikova, Maike Stahlhut, Adrian Schwarzer, Axel Schambach and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Link between mutations inWorld journal of gastrointestinal surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jacob Jalil HassanInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Anna LieskeInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Nicole DörpmundInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Denise KlattInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Dirk HoffmannInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Marc-Jens KleppaInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-4626-3300
Olga S KustikovaInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Maike StahlhutInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Adrian SchwarzerInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Axel SchambachInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Tobias MaetzigInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DEBoston Children's Hospital · US

Funding

Deutsche Forschungsgemeinschaft MA 7010/1Deutsche Forschungsgemeinschaft REBIRTH EXC62/2Deutsche Forschungsgemeinschaft SFB738State of Lower Saxony, Germany MWK: ZN3440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-Cas SystemsGene Expression Regulation, NeoplasticApoptosisBiomarkers, TumorCell ProliferationGroup IV Phospholipases A2High-Throughput Screening AssaysHomeodomain ProteinsHumansLeukemia, Myeloid, AcuteMyeloid Ecotropic Viral Integration Site 1 ProteinTumor Cells, CulturedBiomarkers, TumorGroup IV Phospholipases A2homeobox protein HOXA9Homeodomain ProteinsMEIS1 protein, humanMyeloid Ecotropic Viral Integration Site 1 ProteinPLA2G4A protein, humanacute myeloid leukemiafluorescent genetic barcodingHoxa9lentiviral vectorleukemic stem cellMeis1multiplexingPla2g4ashRNA

Identifiers

PMID34502319
PMCPMC8431012
OpenAlexW3198835081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.