Evidence map›Paper›PMID 34502288›Full record

ArticleInternational journal of molecular sciences2021

ZFP36L2 Role in Thyroid Functionality.

Francesco Albano, Valeria Tucci, Perry J Blackshear, Carla Reale, Luca Roberto, Filomena Russo, Pina Marotta, Immacolata Porreca, Marco Colella, Massimo Mallardo and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Francesco AlbanoIEOS-CNR, 80131 Naples, Italy.ORCID 0000-0001-6157-7688
Valeria TucciBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Perry J BlackshearSignal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Carla RealeBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.ORCID 0000-0001-7682-4784
Luca RobertoBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Filomena RussoBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Pina MarottaStazione Zoologica Anton Dohrn, 80121 Napoli, Italy.ORCID 0000-0001-6857-8325
Immacolata PorrecaBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Marco ColellaBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Massimo MallardoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131 Naples, Italy.
Mario de FeliceIEOS-CNR, 80131 Naples, Italy.ORCID 0000-0003-0009-8725
Concetta AmbrosinoBiogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.ORCID 0000-0003-3954-8842
Biogem · ITUniversity of Sannio · ITInstitute for Experimental Endocrinology and Oncology · ITNational Institute of Environmental Health Sciences · USStazione Zoologica Anton Dohrn · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Naples Federico II · IT

Funding

Goodwater Regione Campania POR Campania FESR 2014/2020 O.S. 1.1 Az. 1.1.3 E 1.1.4-CUP 572 B63D18000150007Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro 12010NIEHS NIH HHS Intramural Research ProgramPOR FESR 2014-2020 Regione Campania RARE PLATNET, SATIN and COEPICASensor Regione Campania 23
6 · The paper itself

Abstract

Thyroid hormone levels are usually genetically determined. Thyrocytes produce a unique set of enzymes that are dedicated to thyroid hormone synthesis. While thyroid transcriptional regulation is well-characterized, post-transcriptional mechanisms have been less investigated. Here, we describe the involvement of ZFP36L2, a protein that stimulates degradation of target mRNAs, in thyroid development and function, by in vivo and in vitro gene targeting in thyrocytes. Thyroid-specific

Indexed as

AnimalsApoptosisCell LineCell SurvivalFemaleGene DeletionGene Expression RegulationMiceMice, Inbred C57BLMice, Mutant StrainsPAX8 Transcription FactorRatsReceptor, Notch1Thyroid GlandThyrotropinTristetraprolinNotch1 protein, mousePax8 protein, mousePAX8 Transcription FactorReceptor, Notch1ThyrotropinTristetraprolinZfp36 protein, mouseapoptosishypothyroidismNisNotch1RNA stabilityZfp36l2 KO

Identifiers

PMID34502288
PMCPMC8431063
OpenAlexW3196831541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.