Evidence map›Paper›PMID 34502266›Full record

ArticleInternational journal of molecular sciences2021

Implication of

Yara A Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A Owen, Akbar Shakoor, Ivana K Kim, Margaret M DeAngelis, Nader Sheibani, Mohamed Al-Shabrawey and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Isolation of Primary Mouse Retinal Pigmented Epithelium Cells.Journal of visualized experiments : JoVE · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yara A SamraDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Dina KiraDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Pragya RajpurohitDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Riyaz MohamedDepartment of Physiology, Medical College of Georgia (MCG), Augusta University, Augusta, GA 30912, USA.
Leah A OwenDepartment of Ophthalmology, Jacobs School of Medicine and Biomedical Engineering, SUNY-University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0003-3802-3868
Akbar ShakoorDepartment of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Ivana K KimRetina Service, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA 02114, USA.
Margaret M DeAngelisDepartment of Ophthalmology, Jacobs School of Medicine and Biomedical Engineering, SUNY-University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0003-3731-142X
Nader SheibaniDepartment of Ophthalmology, Visual Sciences and Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.ORCID 0000-0003-2723-9217
Mohamed Al-ShabraweyDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.
Amany TawfikDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.ORCID 0000-0002-0245-8256
Augusta University · USUniversity of Utah · USOakland University · USMansoura University · EGMassachusetts Eye and Ear Infirmary · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
BMP2/ALKs Signaling System in Diabetic RetinopathyR01EY030054 · NEI · OAKLAND UNIVERSITY · PI Mohamed Al-Sayed Al-Shabrawey · 2020 to 2026
$2.0M
Homocysteine's role in Age-Related Macular DegenerationR01EY029751 · NEI · OAKLAND UNIVERSITY · PI TAWFIK, AMANY M · 2019 to 2023
$1.8M
Systems-Biology Analysis of Mechanisms Informing Preeclampsia-Mediated ROP ProtectionK08EY031800 · NEI · UNIVERSITY OF UTAH · PI OWEN, LEAH A · 2020 to 2022
$497k
NEI NIH HHS K08 EY031800NEI NIH HHS P30 EY016665NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY029751NEI NIH HHS R01 EY029751-01-NEI00072 and R01 EY030054NEI NIH HHS R01 EY030054
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of vision loss. Elevated homocysteine (Hcy) (Hyperhomocysteinemia) (HHcy) has been reported in AMD. We previously reported that HHcy induces AMD-like features. This study suggests that

Indexed as

AgedAged, 80 and overAnimalsCell LineChoroidal NeovascularizationCystathionine beta-SynthaseDisease Models, AnimalEndothelial CellsFemaleHomocysteineHumansHyperhomocysteinemiaHypoxia-Inducible Factor 1, alpha SubunitMacular DegenerationMaleMiceCystathionine beta-SynthaseHif1a protein, mouseHomocysteineHypoxia-Inducible Factor 1, alpha SubunitReceptors, N-Methyl-D-AspartateVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseage-related macular degenerationblood retinal barriercystathionine-β-synthasehomocysteinemouseN-methyl-d-aspartate receptor

Identifiers

PMID34502266
PMCPMC8431693
OpenAlexW3161602643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.