Evidence map›Paper›PMID 34502260›Full record

ArticleInternational journal of molecular sciences2021

Altered DNA Methylation Profiles in

Alicja Pacholewska, Christina Grimm, Carmen D Herling, Matthias Lienhard, Anja Königs, Bernd Timmermann, Janine Altmüller, Oliver Mücke, Hans Christian Reinhardt, Christoph Plass and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Life science alliance · 2023
    Article
  4. Genetics and Epigenetics in Complex Diseases.International journal of molecular sciences · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Alicja PacholewskaInstitute for Translational Epigenetics, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.ORCID 0000-0002-4888-4883
Christina GrimmInstitute for Translational Epigenetics, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.ORCID 0000-0002-4676-8870
Carmen D HerlingCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.
Matthias LienhardDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.ORCID 0000-0002-2549-3142
Anja KönigsInstitute for Translational Epigenetics, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.
Bernd TimmermannSequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Janine AltmüllerCologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Oliver MückeGerman Cancer Research Center, Cancer Epigenomics, 69120 Heidelberg, Germany.
Hans Christian ReinhardtCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.
Christoph PlassGerman Cancer Research Center, Cancer Epigenomics, 69120 Heidelberg, Germany.
Ralf HerwigDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.ORCID 0000-0002-9335-1760
Michael HallekCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.
Michal R SchweigerInstitute for Translational Epigenetics, Faculty of Medicine, University Hospital Cologne, 50931 Cologne, Germany.
University of Cologne · DEGerman Cancer Research Center · DEMax Planck Institute for Molecular Genetics · DEDüsseldorf University Hospital · DE

Funding

Deutsche Forschungsgemeinschaft SFB1399 and SFB1530Deutsche Krebshilfe 1117240Deutsche Krebshilfe 70113041Deutsche Krebshilfe 70113869GO-LONG project SCHW 1605/4-1 and HE 4607/7-1the Centre for Molecular Medicine CMMC A12the Deutsche Jose Carreras Leukämie Stiftung R12/08the German-Israeli Foundation for Research and Development I-65-412.20-2016the German Ministry of Education and Research BMBF e:Med 01ZX1303Athe German Research Foundation KFO-286-RP2 and RE 2246/13-1 ; KFO-286-RP8 ; KFO-286-RP6 ; KFO-286-CP
6 · The paper itself

Abstract

Mutations in splicing factor genes have a severe impact on the survival of cancer patients. Splicing factor 3b subunit 1 (

Indexed as

DNA MethylationGene Expression Regulation, LeukemicMutationBiomarkers, TumorEpigenesis, GeneticHumansLeukemia, Lymphocytic, Chronic, B-CellPhosphoproteinsPrognosisRNA Splicing FactorsBiomarkers, TumorPhosphoproteinsRNA Splicing FactorsSF3B1 protein, humanchronic lymphocytic leukemiaCLLDNA methylationIKAROSNOTCHSF3B1 mutation

Identifiers

PMID34502260
PMCPMC8431484
OpenAlexW3196532439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.