ArticleInternational journal of molecular sciences2021
Anisotropic Chitosan Scaffolds Generated by Electrostatic Flocking Combined with Alginate Hydrogel Support Chondrogenic Differentiation.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- A Novel Chitosan-Modified PLA Doped n-HA Bone Scaffold.Artificial organs · 2026Article
- Bioreactor-Induced Compression in Scaffolds for the Enhancement of Cartilage Regeneration: A Systematic Review.Annals of biomedical engineering · 2026Review
- Ultrasound-activated piezoelectric biomaterials for cartilage regeneration.Ultrasonics sonochemistry · 2025Review
- Article
- Advancements in textile techniques for cardiovascular tissue replacement and repair.APL bioengineering · 2024Review
- Enoki-Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces.Small structures · 2024Article
- How the combination of alginate and chitosan can fabricate a hydrogel with favorable properties for wound healing.Heliyon · 2024Review
- Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications.Theranostics · 2024Review
- Natural based hydrogels promote chondrogenic differentiation of human mesenchymal stem cells.Frontiers in bioengineering and biotechnology · 2024Article
- Extracellular Matrix Secretion Mechanically Reinforces Interlocking Interfaces.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Chitosan-Based Biomaterials for Bone Tissue Engineering Applications: A Short Review.Polymers · 2022Review
- Stepwise Proliferation and Chondrogenic Differentiation of Mesenchymal Stem Cells in Collagen Sponges under Different Microenvironments.International journal of molecular sciences · 2022Article
- Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration.International journal of molecular sciences · 2022Review
- Understanding and utilizing textile-based electrostatic flocking for biomedical applications.Applied physics reviews · 2021Review
- Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering.Materials today. Bio · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The replacement of damaged or degenerated articular cartilage tissue remains a challenge, as this non-vascularized tissue has a very limited self-healing capacity. Therefore, tissue engineering (TE) of cartilage is a promising treatment option. Although significant progress has been made in recent years, there is still a lack of scaffolds that ensure the formation of functional cartilage tissue while meeting the mechanical requirements for chondrogenic TE. In this article, we report the application of flock technology, a common process in the modern textile industry, to produce flock scaffolds made of chitosan (a biodegradable and biocompatible biopolymer) for chondrogenic TE. By combining an alginate hydrogel with a chitosan flock scaffold (CFS+ALG), a fiber-reinforced hydrogel with anisotropic properties was developed to support chondrogenic differentiation of embedded human chondrocytes. Pure alginate hydrogels (ALG) and pure chitosan flock scaffolds (CFS) were studied as controls. Morphology of primary human chondrocytes analyzed by cLSM and SEM showed a round, chondrogenic phenotype in CFS+ALG and ALG after 21 days of differentiation, whereas chondrocytes on CFS formed spheroids. The compressive strength of CFS+ALG was higher than the compressive strength of ALG and CFS alone. Chondrocytes embedded in CFS+ALG showed gene expression of chondrogenic markers (
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