Evidence map›Paper›PMID 34502243›Full record

ArticleInternational journal of molecular sciences2021

In Situ Hydroxyapatite Synthesis Enhances Biocompatibility of PVA/HA Hydrogels.

Petra Chocholata, Vlastimil Kulda, Jana Dvorakova, Monika Supova, Margit Zaloudkova, Vaclav Babuska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petra ChocholataDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic.
Vlastimil KuldaDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic.ORCID 0000-0001-7926-994X
Jana DvorakovaDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic.
Monika SupovaDepartment of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Academy of Sciences of the Czech Republic, V Holesovickach 41, 182 09 Prague, Czech Republic.
Margit ZaloudkovaDepartment of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Academy of Sciences of the Czech Republic, V Holesovickach 41, 182 09 Prague, Czech Republic.
Vaclav BabuskaDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic.ORCID 0000-0001-9296-9414

Funding

Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_019/0000787Ministerstvo Školství, Mládeže a Tělovýchovy SVV 2020-260 540
6 · The paper itself

Abstract

Bone tissue engineering tries to simulate natural behavior of hard tissues. This study aimed to produce scaffolds based on polyvinyl alcohol (PVA) and hyaluronic acid (HA) with hydroxyapatite (HAp) incorporated in two different ways, by in situ synthesis and physical mixing of pre-prepared HAp. In situ synthesis resulted in calcium deficient form of HAp with lower crystallinity. The proliferation of human osteoblast-like cells MG-63 proved to be better in the scaffolds with in situ synthesized HAp compared to those with physically mixed pre-prepared HAp. For scaffolds with PVA/HA/HAp ratio 3:1:2, there was significantly higher initial adhesion (

Indexed as

Biocompatible MaterialsCell AdhesionCell ProliferationCell SurvivalDurapatiteHemolysisHumansHyaluronic AcidHydrogelsMaterials TestingOsteoblastsPolyvinyl AlcoholTissue EngineeringTissue ScaffoldsBiocompatible MaterialsDurapatiteHyaluronic AcidHydrogelsPolyvinyl Alcoholbiological evaluationbone tissue engineeringcell viabilityhyaluronic acidhydrogelhydroxyapatitein situ synthesispolyvinyl alcoholscaffold

Identifiers

PMID34502243
PMCPMC8431644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.