Evidence map›Paper›PMID 34502207›Full record

ArticleInternational journal of molecular sciences2021

Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis.

Chiara Gramegna Tota, Beatrice Valenti, Antonella Forlino, Antonio Rossi, Chiara Paganini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chiara Gramegna TotaDepartment of Molecular Medicine, Unit of Biochemistry, University of Pavia, 27100 Pavia, Italy.
Beatrice ValentiDepartment of Molecular Medicine, Unit of Biochemistry, University of Pavia, 27100 Pavia, Italy.
Antonella ForlinoDepartment of Molecular Medicine, Unit of Biochemistry, University of Pavia, 27100 Pavia, Italy.
Antonio RossiDepartment of Molecular Medicine, Unit of Biochemistry, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2460-8761
Chiara PaganiniDepartment of Molecular Medicine, Unit of Biochemistry, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-1709-6339
University of Pavia · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza 2018-2022
6 · The paper itself

Abstract

The complexity of skeletal pathologies makes use of in vivo models essential to elucidate the pathogenesis of the diseases; nevertheless, chondrocyte and osteoblast cell lines provide relevant information on the underlying disease mechanisms. Due to the limitations of primary chondrocytes, immortalized cells represent a unique tool to overcome this problem since they grow very easily for several passages. However, in the immortalization procedure the cells might lose the original phenotype; thus, these cell lines should be deeply characterized before their use. We immortalized primary chondrocytes from a

Indexed as

PhenotypeAcid Anhydride HydrolasesAnimalsCell Line, TransformedChondrocytesCraniofacial AbnormalitiesDwarfismGlycosaminoglycansJoint InstabilityMiceMice, Inbred C57BLMice, KnockoutOssification, HeterotopicPolydactylyAcid Anhydride HydrolasesCant1 protein, mouseGlycosaminoglycanscartilagecollagenextracellular matriximmortalizationin vitro modelproteoglycanskeletal dysplasia

Identifiers

PMID34502207
PMCPMC8431031
OpenAlexW3198577130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.