Evidence map›Paper›PMID 34502197›Full record

ReviewInternational journal of molecular sciences2021

The Role of Epigenetic Factors in Psoriasis.

Klaudia Dopytalska, Piotr Ciechanowicz, Kacper Wiszniewski, Elżbieta Szymańska, Irena Walecka

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Klaudia DopytalskaCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.
Piotr CiechanowiczCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.
Kacper WiszniewskiCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.
Elżbieta SzymańskaCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.
Irena WaleckaCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.ORCID 0000-0002-3502-3339
Central Clinical Hospital · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic, systemic, immune-mediated disease with an incidence of approximately 2%. The pathogenesis of the disease is complex and not yet fully understood. Genetic factors play a significant role in the pathogenesis of the disease. In predisposed individuals, multiple trigger factors may contribute to disease onset and exacerbations of symptoms. Environmental factors (stress, infections, certain medications, nicotinism, alcohol, obesity) play a significant role in the pathogenesis of psoriasis. In addition, epigenetic mechanisms are considered result in modulation of individual gene expression and an increased likelihood of the disease. Studies highlight the significant role of epigenetic factors in the etiology and pathogenesis of psoriasis. Epigenetic mechanisms in psoriasis include DNA methylation, histone modifications and non-coding RNAs. Epigenetic mechanisms induce gene expression changes under the influence of chemical modifications of DNA and histones, which alter chromatin structure and activate transcription factors of selected genes, thus leading to translation of new mRNA without affecting the DNA sequence. Epigenetic factors can regulate gene expression at the transcriptional (via histone modification, DNA methylation) and posttranscriptional levels (via microRNAs and long non-coding RNAs). This study aims to present and discuss the different epigenetic mechanisms in psoriasis based on a review of the available literature.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression RegulationProtein Processing, Post-TranslationalAnimalsHumansPsoriasisdermatologyDNA methylationepigeneticsnon-coding RNApsoriasis

Identifiers

PMID34502197
PMCPMC8431057
OpenAlexW3196471353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.